ASPM_SAGLB
ID ASPM_SAGLB Reviewed; 1527 AA.
AC P62295;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
DE Flags: Fragment;
GN Name=ASPM;
OS Saguinus labiatus (Red-chested mustached tamarin).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Saguinus.
OX NCBI_TaxID=78454;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15045028; DOI=10.1371/journal.pbio.0020126;
RA Kouprina N., Pavlicek A., Mochida G.H., Solomon G., Gersch W., Yoon Y.-H.,
RA Collura R., Ruvolo M., Barrett J.C., Woods C.G., Walsh C.A., Jurka J.,
RA Larionov V.;
RT "Accelerated evolution of the ASPM gene controlling brain size begins prior
RT to human brain expansion.";
RL PLoS Biol. 2:653-663(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY497015; AAS48531.1; -; Genomic_DNA.
DR AlphaFoldDB; P62295; -.
DR SMR; P62295; -.
DR PRIDE; P62295; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 4.
DR Pfam; PF00612; IQ; 34.
DR SMART; SM00015; IQ; 51.
DR SUPFAM; SSF52540; SSF52540; 16.
DR PROSITE; PS50096; IQ; 30.
PE 3: Inferred from homology;
KW Calmodulin-binding; Cell cycle; Cell division; Cytoplasm; Cytoskeleton;
KW Mitosis; Nucleus; Repeat.
FT CHAIN <1..>1527
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191339"
FT DOMAIN 35..66
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 175..206
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 225..254
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 248..277
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 321..350
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 344..375
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 394..423
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 417..446
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 467..496
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 490..521
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 563..594
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 613..642
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 636..667
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 686..717
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 709..740
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 759..790
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 832..863
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 855..886
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 904..935
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 927..958
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 977..1006
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1000..1031
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1050..1081
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1123..1154
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1259..1288
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1282..1313
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1332..1361
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1408..1439
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1456..1487
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1506..>1527
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT NON_TER 1
FT NON_TER 1527
SQ SEQUENCE 1527 AA; 184736 MW; 9D1CDA97075DA454 CRC64;
LRGNQVHQGS KMLKSSFLVI QVMFRRWKRR KMQLQVKAAV TLQRAFREWH LRKRAKEEKS
AIVIQSWYRM HKQLQKYAYV RACVVIIQKR FRCFQAQKLY KRRKESILTI QKYYRAYLKG
KIERTNYLQK RAAAIQLQAA FRRLKAHRLR RQIRAACVIQ SYWRMRQDRV RFLNHRKIII
KLQAHVRKHQ QLQKYKKMKK AAVVIQTRFQ AYIFARKVLA SYQKTRSAVI LLQSAYRGMQ
ARKMYIQIPT SVIKIQPYYR AYVSKKEFLS LKNATIKLQS IVKMKQTRKQ YLHLRATAVF
IQQHYRSKKL AAQKREEYMQ MRESCIKLQA FVRGYLVRKQ MRLQRKAVIS LQSYYRMRKA
RQCYLKMYKV VIIIQNYYHS YKAQVNQRKN FLQVKKAATC LQAAYRGYKV RQLIKQQSIA
AVKIQSAFRG YSKRVRYQSV LQSIIKIQRW YRAYKTLSDI RTHFLKTKAA VISLQSAYRG
WKVRKQIRRE HQAAMKIQSA FRMAKAQKQF RLFKTAALVI QQHLRAWSTG RKQHMQYIEL
RHPVLMLQSM WKGKTLRRRL QRQHKCAVII QSYYRMHVQQ KKWKTMKKAA LLIQKYYRAY
SIGREQHHLY LETKAAVVTL QSAYRGMKVR KRIKDCKKAA VTIQSKYRAY KTKKKYAAYR
SSAIIIQRWY RGIKITNHQY KEYHSLKKTV IKIQAVYRGI RIRRHIQHMH RAATFIKAMF
KMHQSRIRYH TMRKAAIVIQ VRYRAYYQGK MQRENYLKIL RAVNVLQANF RGVRLRRTLR
NLQIAATVIQ SNYRRYREQT YFNKLKKITK TVQQRYRAVK ERNILFQRYN KLRHSVIYIQ
AVFRGMKARR HLKTMHLAAT LIQRRFRTLM MRRRFLSLKK TAIWIQRKYR AHLCTKHHLQ
FLLLQNAAIK IQSSYRRWMI RKRMREMHRA ATFIQATFRM HRVHRRYQAL KQASAMIQQQ
YQANRAAKLQ RQHYLRQRHS AVILQAAFRG MKTRRHLKSM HSSAVRIQSR FRSLLVRRRF
ISLKKAAIFI QRKYRATICA KHKLHQFLKL RKAAITIQSS YRRLMVKKKL QEVHRAAVLI
QATFRMHRTY LTFQTWKHAS ILIQQHYRTY RASKLQRENY TKQWRSAVII QAAYRGMKAR
QLLREKHKAA VIIQSTYRMY RQYCLYQNLQ WATKIIQEKY RANKKKHKAL QHNELKKAET
CVQASFQDMN IKKLIQEQHQ TSIIIQKHCK AFKIKKHYLH LREPVVSIQR RYRKLTAVHT
QAVICIQSYY RGFKVRRDIQ NMHLAATRIQ SFYRMHRAKV DYQTKKTAIV VIQNYYRLYV
RVKTERRNFL AVQKSVRTIQ AAFRGMKVRQ KLKNVSQEKI AAIVNRSALY CYGSKAQCEA
VGSEGVIIQE WYKASCFACS QEAEYRSQSR AAVTIQKAFR RMITRKLDTR KCAALRIQFF
LQMAVYRRRR ANFVQQKRAA VTLQHYFRMW QTRKQFLLYR KAAVVLQNHY RAFLSGKHQR
QVYLQIRSSV IIIQARIKGF IQKRKFQ
