ID   PD5BB_XENLA             Reviewed;        1464 AA.
AC   Q5U241;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Sister chromatid cohesion protein PDS5 homolog B-B;
DE   AltName: Full=Androgen-induced proliferation inhibitor B;
GN   Name=pds5b-b; Synonyms=aprin-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH86289.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000312|EMBL:AAH86289.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in androgen-induced proliferative arrest.
CC       Required for maintenance of sister chromatid cohesion during mitosis
CC       (By similarity). {ECO:0000250|UniProtKB:Q9NTI5}.
CC   -!- SUBUNIT: Interacts with the cohesin complex.
CC       {ECO:0000250|UniProtKB:Q9NTI5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6TRW4}.
CC   -!- PTM: Phosphorylated in mitotic cells. {ECO:0000250|UniProtKB:Q498H0}.
CC   -!- SIMILARITY: Belongs to the PDS5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH86289.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC086289; AAH86289.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001088643.2; NM_001095174.2.
DR   AlphaFoldDB; Q5U241; -.
DR   SMR; Q5U241; -.
DR   IntAct; Q5U241; 1.
DR   GeneID; 495695; -.
DR   KEGG; xla:495695; -.
DR   CTD; 495695; -.
DR   Xenbase; XB-GENE-6041384; pds5b.S.
DR   OrthoDB; 69768at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 495695; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007064; P:mitotic sister chromatid cohesion; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR   InterPro; IPR039776; Pds5.
DR   PANTHER; PTHR12663; PTHR12663; 1.
DR   SMART; SM00384; AT_hook; 3.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..1464
FT                   /note="Sister chromatid cohesion protein PDS5 homolog B-B"
FT                   /id="PRO_0000287428"
FT   REPEAT          383..419
FT                   /note="HEAT"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        1287..1299
FT                   /note="A.T hook 1"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        1375..1387
FT                   /note="A.T hook 2"
FT                   /evidence="ECO:0000255"
FT   DNA_BIND        1391..1403
FT                   /note="A.T hook 3"
FT                   /evidence="ECO:0000255"
FT   REGION          1126..1464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1132..1170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1196..1287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1338..1357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1358..1372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1464 AA;  166925 MW;  2D1AA6281B01AA72 CRC64;
     MALSKAKGND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKEQYLNLA
     LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT
     KSPQFNRYFY LLENIAWVKS YNICFELEDC NEIFTQLYRT LFSVINNGHN QKVHMHMVDL
     MSSIVCEGDT VSQELLDSVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV
     LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
     GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHS LMNHPDLAKD LTEYLKVRSH
     DPEEAIRHDV IVSIVTAAKK DLLLVNDQLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYS
     LQVEAGKESA KQISWIKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET TERMKCLYYL
     YATLDTNAVK ALNEMWKCQN MLRHHVKDLL DLIKKPKTEA GSKAIFSKVM VITKNLPDPG
     KGQDFLKKFT QVLEDDEKIR GQLEKLVSPT CSYKQAEVCV RDITKKLGNP KQPTNPFLEM
     IKFLLERIAP VHIDTESISS LIKLVNKSID GTADDEDEGV PTDQAIRAGL ELLKVLSFTH
     PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGNKIE EDFPHIRSAL LPVLQQKAKK
     GSPRQAKYSI HCIHAIFSSK ETQFAQIFEP LHKSLDPGNP EQLITSLVTI GHIAQLAPDQ
     FTAPLKSMVA TFVVKDLLMS DQLPGKKTTK LWVPDDEVSQ ETMVKIQAIK MMVRWLLGMK
     NNLSKSGNST LRLLTAILHT DGDLTEHGKL SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
     LEQYQLCALV INDECYQVRQ LFAQKLHKGL SRLRLPLEYM AICALCAKDP VKERRAHARQ
     CLVKNINVRR EYLKQHAAVS EKLFSLLPEY VVPYTVHLLT HDPDYVKVQD IEQLKDIKEC
     LWFVLEILMS KNENNSHAFI RKMVEYIKQT KDAQNPDDQK MNEKMYTVCD VAMNIIISKS
     TTYSLESPKD PVLPARFFTQ PDKNFSNTKH YLPAELKSFF TPGKPKSTNV LGAVNKPLSS
     AGKQMQSKSS RMETVSNASS GSNPSSPGRI KGRLDSTELD QIEYEDYTMI SSPLSGKKSD
     KRDDSDLLKS EVEKPRRGRK QPLIDPDDSF SMDELSKPAQ EPKSRTSQRG RKRAAAASES
     EEQAWQEKRL KEDLLENEDE QNSPPKKGRR GRPPKSAKMA ISKEEPPVTT PKRGRKNVVP
     IESPPTDEED HLEISEEQDS ENIDQKRKGR GSSKKTPQKS DSTDSALDTS RPTPQKRRGR
     PPKTPTVQQK KSHVGRPRKV VSKEPESEEE MEISQNSPAL SENISNEEET ADEEVVAPST
     GRRRTAKKRR WIQRMKSELE GPLL