ASPM_SAIBB
ID ASPM_SAIBB Reviewed; 3469 AA.
AC P62296;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 82.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
GN Name=ASPM;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY485419; AAR98740.1; -; mRNA.
DR RefSeq; NP_001266913.1; NM_001279984.1.
DR STRING; 39432.ENSSBOP00000014090; -.
DR PRIDE; P62296; -.
DR GeneID; 101029242; -.
DR CTD; 259266; -.
DR OrthoDB; 482623at2759; -.
DR Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 39.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 61.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 38.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..3469
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191340"
FT DOMAIN 911..1047
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1101..1252
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1338..1369
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1384..1413
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1573..1604
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1623..1652
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1646..1675
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1669..1700
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1719..1748
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1742..1773
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1792..1821
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1815..1844
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1865..1894
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1888..1919
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1938..1969
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1961..1992
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2011..2040
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2034..2065
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2084..2115
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2107..2138
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2157..2188
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2180..2209
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2230..2261
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2253..2284
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2302..2333
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2325..2356
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2375..2406
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2398..2429
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2448..2479
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2521..2552
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2657..2686
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2680..2711
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2730..2759
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2806..2837
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2851..2882
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2901..2930
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2946..2977
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3021..3050
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3071..3102
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3173..3202
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 467..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1048..1069
FT /evidence="ECO:0000255"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 282
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 391
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 419
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 599
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1094
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
SQ SEQUENCE 3469 AA; 408504 MW; C7DF7F7D3ED7D683 CRC64;
MATRRVGRGC WEVSPTERRP CAGLRGPAAE EEAASPPVLF LSHFCRSPFL CFGDVRLGTS
RTLPLTLDNP NEEVAEVEIS HLPAADLGFS VSQRRFVLQP KEKIVISVNW TPFKEGRVRE
TMTFLVNDVL KHQAILLGNA EEQKKKKRNL WDTIKKKKIS ASTSHNRRVS NIQNVKTFSV
SQKVDRVRSP LHACENLAMN EGGPPTENNH LTLEENKILI SPISPAFSEC HGATCLPLSV
RRSTAYSSLH ALENRELLNV DSANVSKDNF NEKVVSETSF NSINVSDQSG ENNKLILTPN
YSSTLNITQS QRNFLSPDSF VNNSHGENNE LELGTCLSSD MFMKDNPKPM LLESTTAREM
YQKILSPDSF IKDNYGLNQN LESESVXSIL SPNQMACMCT SQQTYKVPSS NENSQVPQSL
QDWRKSKVFP CVPECQGSKS PKATFEELVE MKSNCCSFIK QNQPKFPAVK DISSHSHNKQ
PKRRPILSAT VTKRKPTRTR ENQTEINKPK AKRCLNSAVG ENEKIINNQK EKEDFYSYLP
IIDPVLSKSK SYKNEITPSL TTASVARKRK SDGSMGDANE RVAVTEHTEV QEIKRIHFSP
SEPKTATVKK TKNVITPISK CVSNREKLSL KKKTEFKTPI FKTSKRTKPI IAVAQSNLTF
IKSLKTDIPR HPMPFAAKNM FYDERWKEKQ EQGFTWWLNF ILTPDDFTVK TNISEVNAAT
LLLGVENQHK ISVPRAPTKE EMSLRAYTAR CMLNRLRRAA CRLFTSEKMV KAIKKLEIEI
EARRLVVRKD RHLWKDVGER QKVLNWLLSY NPLWLRIGLE TVYGELISLE DNSDVTGLAV
FILSRLLWNP DIAAEYRHPT VPHLYGDGHE EALSKFTLKK LLLLVCFLDY AKISRLIDHD
PCLFCKDAEF KASKEILLAF SRDFLSGEGD LSRHLGLLGL PVNHVQTPFD EFDFAVTNLA
VDLQCGVRLV RTMELLTQNW DLSKKLRIPA ISRLQKMHNV DIVLQVLKSR GIELSDEHGN
TILSKNIVDR HREKTLGLLW KIVFAFQVNI SLNLDQLKEE IAFLKHTKSI KKTVSLLSCH
SDALTNKKKG KRDSGSFEQY GENIKLLMDW VNAVCAFYNK KVENFTVSFS DGRVLCYLIH
HYHPCYVPFD AISQRTTQTV ECTHTGSVVL NSSSESDESS LDMSLKAFDQ ENTSELYKEL
LENEKKNFHL VRSAVRDLGG IPAMINHSDM SNTIPDEKVV ITYLSFLCAR LLDLRKEIRA
ARLIQTTWRK YKLKTDLKRH QERDKAARII QSAVINFLRK QRLRKTLNAA LIIQKYWRRV
LAQKKLLMLK KEKLERVQNK AASLIQGYWR RYSTRKRFLK LKYYSIVLQS RIRMIIAVTC
YKRYLWATVT IQRHWRASLR RKQDQQRYEK LKSSSLIIQA MFRRWKQRKM QLQVKATITL
QRAFREWHLR KRAKEEKSAI VIQSWYRMHK QLRKYVYVRS CVVIIQKRFR CFQAQKLYKR
RKESILTIQK YYRAYLKGKI ERTNYLQKRA AAIQLQAAFR RLKAHNLHRQ IRAACVIQSY
WRMRQDRVRF LNLKKIIIKL QAHVRKHQQL RKYKKMKKAA VIIQTHFQAY IFARKVLASY
QKTRSAVIVL QSAYRGMQAR KMYIHILTSV IKIQSYYRAY VSKKEFLSLK NATIKLQSIV
RMKQTRKQYL HLRATALFIQ QCYHSKKLAA QKREEYMQMR ESCIKLQAFV RGYLVRKQMR
LQRKAVISLQ SYFRMRKSRQ YYLKMYKAVI IIQNYYHSYK AQVNQRKNFL QVKKAATCLQ
AAYRGYKVRQ LIKQQSVAAV KIQSAFRGYS KRVKYQSVLQ SIIKIQRWYR AYKTLHGIRT
HFLKTKAAVI SLQSAYRGWK VRKQIRREHQ AAMKIQSAFR MAKAQKQFRL FKTAALVIQQ
HLRAWTAGRK QRMEYIELRH SVLMLQSMWK GKALRRQLQR QHKCAVIIQS YYRMHVQQKK
WKIMKKAALL IQKYYRAYSI GREQHCLYLK TKAAVVTLQS AYRGMKVRKR IKDCNKAAIT
IQSKYRAYKT KKKYAAYRAS AIIIQRWYRS IKITNHQYKE YLNLKKTAIK IQAVYRGIRV
RRHIQCMHRA ATFIKAMFKM HQSRIRYHTM RKATIVIQVR YRAYYQGKMQ REDYLKFLKA
VNVLQANFRG VRVRRTLRKL QIAATVIQSN YRRYRQQTYF NKLKKITKTV QQRYRAVKER
NIQFQRYNKL RHSVIHIQAI FRGMKVRRHL KTMHIAATLI QRRFRTLMMR RRFLSLKKTA
IWIQRKYRAH LCTKHHLQFL RLQNAAIKIQ SSYRRWVVRK KMREMHRAAT FIQATFRMHR
VHMRYQALKQ ASVVIQQQYQ ANRAAKLQRQ HYLRQRHSAV ILQAAFRGME TRRRLKSMHS
SAILIQSRFR SLLVRRRFIS LKKAAIFIQR KYRATICAKH NLHQFLQLRK AAVTIQSSYR
RLMVKKKLQE MHRAAVLIQA TFRMHKTYIT FQTWKHASIL IQQHYRTYRA SKLQRENYTK
QWHSALIIQA AYRGMKARQL LREKRKAAII IQSTYRMYRQ YCLYQNLQWA TKIIQEKYRA
NKKKHKALQH NELKKAEACV QASFQDMNIK KLIQEQHQTS LTIQKHCNAF KIKKQYLHLR
APVVSIQRRY RKLTAVHTQA VICIQSYYRG FKVRRDIQNM HLAATRIQSL YRMHRAKVDY
QTKKTAIVVI QNYYRLYVRV KTERNSFLAV QKSVRTIQAA FRSMKVRQKL KNLSQEKMAA
IVSPSAVYCY RIEAQSEAVG SEGVIIQEWY KTSCLAHSQE AEYHSQSRAA VTIQKAFRRM
ITRKLETQKC AALRIQFFLQ MAVYRRRFVQ QKRAAVTLQH YFRTWQTRKQ FLLYRKAAVV
LQNHYRAFLS AKHQRQVYLQ IRSSVIIIQA RTKGFIQKRK FQKIKNSTIK IQAVWRRYRD
KKSLCKVKAA CKIQAWYRCW RAHKEYLAIL KAVKIIQGSF YXKLERTRFL NMRASAIIIQ
RKWRAILSAK IAHEHFLMIQ RHQAACLIQA HFRGYKGRQV FLRQKSAALN IQKYIRAREA
GRRERIKYIE LKKSTVTLQA LVRGWLVRKR ILEQRAKIRL LHFTAAAYYH LKALRIQRAY
KLYLALKNAN KQVNSAICIQ RWFRARLQQK RFIQICHSIK KIEHEGQERL SQQNRAASVI
QKAVRHFLLR KKQEKFTSGI IKFQALWRGY SWRKNNDCTK IKAIRLSLQV VNREIREENK
LYRRAALALH YLLTYKHLSA ILEAVKHLEV VTRLSPFCCE NMAQSGAISK IFVLIRSCNR
SVPCMEVIRY AVQVLLNVAK YEKTTSAVYD VENCVDTLLE LLQMYREKPG NKVADKSGSI
FTKTCCLLAT LLKTTNRASD VRSRSKVVDR IYSLYKLTAY KHKVNTERLH YKQKKDSSTS
IPFIPETPVR TRIVSRLKPD WVLRRDNLEE ITNPLQAIQM VMDTLGIPY
