PDAD2_ARCFU
ID PDAD2_ARCFU Reviewed; 157 AA.
AC O30240;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Pyruvoyl-dependent arginine decarboxylase 2;
DE Short=PvlArgDC 2;
DE EC=4.1.1.19;
DE Contains:
DE RecName: Full=Pyruvoyl-dependent arginine decarboxylase 2 subunit beta;
DE Contains:
DE RecName: Full=Pyruvoyl-dependent arginine decarboxylase 2 subunit alpha;
GN Name=pdaD2; OrderedLocusNames=AF_2431;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:58145; EC=4.1.1.19;
CC -!- COFACTOR:
CC Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence={ECO:0000250};
CC Note=Binds 1 pyruvoyl group covalently per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the PdaD family. {ECO:0000305}.
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DR EMBL; AE000782; AAB91232.1; -; Genomic_DNA.
DR PIR; H69553; H69553.
DR RefSeq; WP_010879918.1; NC_000917.1.
DR AlphaFoldDB; O30240; -.
DR SMR; O30240; -.
DR STRING; 224325.AF_2431; -.
DR EnsemblBacteria; AAB91232; AAB91232; AF_2431.
DR GeneID; 24796155; -.
DR KEGG; afu:AF_2431; -.
DR eggNOG; arCOG04490; Archaea.
DR HOGENOM; CLU_114389_0_0_2; -.
DR OMA; SEHHSFG; -.
DR OrthoDB; 98606at2157; -.
DR PhylomeDB; O30240; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0008792; F:arginine decarboxylase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006527; P:arginine catabolic process; IEA:InterPro.
DR Gene3D; 3.50.20.10; -; 1.
DR HAMAP; MF_01404; PvlArgDC; 1.
DR InterPro; IPR016104; Pyr-dep_his/arg-deCO2ase.
DR InterPro; IPR016105; Pyr-dep_his/arg-deCO2ase_sand.
DR InterPro; IPR002724; Pyruvoyl-dep_arg_deCO2ase.
DR PANTHER; PTHR40438; PTHR40438; 1.
DR Pfam; PF01862; PvlArgDC; 1.
DR PIRSF; PIRSF005216; Pyruvoyl-dep_arg_deCO2ase; 1.
DR SFLD; SFLDG01170; Pyruvoyl-dependent_arginine_de; 1.
DR SUPFAM; SSF56271; SSF56271; 1.
DR TIGRFAMs; TIGR00286; TIGR00286; 1.
PE 3: Inferred from homology;
KW Decarboxylase; Lyase; Pyruvate; Reference proteome.
FT CHAIN 1..42
FT /note="Pyruvoyl-dependent arginine decarboxylase 2 subunit
FT beta"
FT /evidence="ECO:0000250"
FT /id="PRO_0000023306"
FT CHAIN 43..157
FT /note="Pyruvoyl-dependent arginine decarboxylase 2 subunit
FT alpha"
FT /evidence="ECO:0000250"
FT /id="PRO_0000023307"
FT SITE 42..43
FT /note="Cleavage (non-hydrolytic)"
FT /evidence="ECO:0000250"
FT MOD_RES 43
FT /note="Pyruvic acid (Ser)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 157 AA; 17165 MW; F39D137F73862679 CRC64;
MALIPKEVFF VSGVGRHEDE LVSFELALRD AGIERFNLVP VSSIVPPGCR VVSKEEGLRK
LSPGQIVFCV MARYASNVEG REIFASVGAA FPEDKDMNGY IAEHSGEWYE GAEQHAKRLA
EEMLKTQGSK VARTFAITAR GKVKEFTTAV AAAVFVI