ASPM_SHEEP
ID ASPM_SHEEP Reviewed; 3374 AA.
AC P62297;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 23-FEB-2022, entry version 83.
DE RecName: Full=Abnormal spindle-like microcephaly-associated protein homolog;
DE Flags: Fragment;
GN Name=ASPM;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14722158; DOI=10.1093/hmg/ddh055;
RA Evans P.D., Anderson J.R., Vallender E.J., Gilbert S.L., Malcom C.M.,
RA Dorus S., Lahn B.T.;
RT "Adaptive evolution of ASPM, a major determinant of cerebral cortical size
RT in humans.";
RL Hum. Mol. Genet. 13:489-494(2004).
CC -!- FUNCTION: Probable role in mitotic spindle regulation and coordination
CC of mitotic processes. May have a preferential role in regulating
CC neurogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Nucleus {ECO:0000250}. Note=The nuclear-
CC cytoplasmic distribution could be regulated by the availability of
CC calmodulin. Localizes to spindle poles during mitosis (By similarity).
CC {ECO:0000250}.
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DR EMBL; AY485423; AAR98744.1; -; mRNA.
DR STRING; 9940.ENSOARP00000015786; -.
DR PRIDE; P62297; -.
DR eggNOG; KOG0160; Eukaryota.
DR eggNOG; KOG0165; Eukaryota.
DR Proteomes; UP000002356; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 2.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR029955; ASPM.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22590:SF4; PTHR22590:SF4; 6.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 41.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 64.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF52540; SSF52540; 17.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 41.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN <1..>3374
FT /note="Abnormal spindle-like microcephaly-associated
FT protein homolog"
FT /id="PRO_0000191341"
FT DOMAIN 855..991
FT /note="Calponin-homology (CH) 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1045..1196
FT /note="Calponin-homology (CH) 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 1201..1230
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1282..1313
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1472..1503
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1567..1596
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1590..1619
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1613..1642
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1647..1678
FT /note="IQ 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1720..1749
FT /note="IQ 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1743..1772
FT /note="IQ 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1793..1822
FT /note="IQ 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1816..1847
FT /note="IQ 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1866..1897
FT /note="IQ 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1939..1968
FT /note="IQ 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1962..1993
FT /note="IQ 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2012..2043
FT /note="IQ 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2035..2066
FT /note="IQ 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2085..2116
FT /note="IQ 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2108..2137
FT /note="IQ 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2158..2189
FT /note="IQ 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2181..2212
FT /note="IQ 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2230..2261
FT /note="IQ 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2253..2284
FT /note="IQ 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2303..2334
FT /note="IQ 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2326..2357
FT /note="IQ 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2376..2407
FT /note="IQ 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2399..2430
FT /note="IQ 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2449..2480
FT /note="IQ 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2472..2503
FT /note="IQ 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2542..2573
FT /note="IQ 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2583..2612
FT /note="IQ 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2606..2637
FT /note="IQ 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2656..2685
FT /note="IQ 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2732..2763
FT /note="IQ 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2777..2806
FT /note="IQ 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2827..2856
FT /note="IQ 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2850..2881
FT /note="IQ 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2872..2903
FT /note="IQ 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2947..2976
FT /note="IQ 38"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 2997..3028
FT /note="IQ 39"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3099..3128
FT /note="IQ 40"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 3122..3153
FT /note="IQ 41"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 181..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 992..1013
FT /evidence="ECO:0000255"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 215
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 300
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 325
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT MOD_RES 1038
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IZT6"
FT NON_TER 1
FT NON_TER 3374
SQ SEQUENCE 3374 AA; 395702 MW; 5B6DE284CBD74994 CRC64;
PNEEAAAVRL SRGPAAERGF TIWPXAFVLQ PKEKIVVSIT WTPLKGGRVR ETVTFLVNDI
LKHQAILLGN AEEPKKKKRT LWDTINKKKV SASSRHNKKV SNIQNVNKTF NVSPKADKVR
SPLQACENLA TNGNCSPPES NPLILEENKL PISPISPAFQ ECHRETCLPL HVRRSTTYTS
LPASENGELE KADGANTAKD FHFNEKGITE TSFDSIDNVN SQTEENGKLT LTPNYSSSLN
ITQSQGHFLS PDSFVNNSHA SNNEPEFVKC LSPDMFVKGN TRPVLLESKR VHEICRKILS
PDSFINDNYG LNEDLETESV NPILSPNQFL KDNIAYICIS QQTCQLPLST RRFQDSQPPQ
DERKNAAVPC ISECQQLESP KATFEASKAL EVMSNSYTFK KQNQPKFSAV QDISSHSREK
PIKRRPILSA TVTKRKPTCA VXNQMETVKP KAKRCLNVVV GDCEKETDDQ KEKDDFHPLL
PTRDLILSRP KSSKNIVTPP CKAASVARKR KSKGHTGDEN VRVRVTECSE VQEVKRTHFS
PLASKTSTVK HTHKVLTSSL KRVSHREKVN LKRKTDSLGY RTPTSKTNKR TRPFVPVAQS
NLTFIKALKA GIPRHPMPFA AKNIFYDERW KEKQEQGFTW WLNFILTPDD FTVKTNISEV
NASTLLLGVE SQHKISVPKA PTKDEVSLRA YTARCRLNRL RRAACRLFTS EKMVKAMKKL
EIEIEARRLI VRKDRHLWKD VGERQKVLNW LLSYNPLWLR IGLETIYGEL VPLEDNSDVT
GLAMFILNRL LWNPDIAAEY RHPSVPHLYR DGHEEALSKF TLKKLLLLVC FLDYAKISRL
IDHDPCLFCK DAEFKASXDI LLAFSRDFLG GEGDLSRHLS LLGFPVTHVQ MPFDEFDFAV
KNLAVDLQCG VRLVRTMELL TQNWNLSKKL RIPAISRLQK MHNVDIVLEI LKSRGIQLND
EHGNAILSKD IVDRHREKTL ALLWKIALAF QVDISLNLDQ LKEEIDFLKK TQSMKKTMSA
LLCRPDAVIS KKRDERHSGP FEQYSESVKL LMDWVNAVCG FYNKKVENFT VSFSDGRVLC
YLIHHYHPCY VPFDAICQRT TQTVECTHTG SVVLNSSSES DGSFLDLSXK SPDQENTSEL
YKELLENEKK NFQLVRSAAR DLGGIPAMIH HSDMSNTIPD EKVVITYLSF LCARLLDLRK
ETRAARLIQT TWRQYKLKKD LKHHQERDKA ARIIQSAIIN FLTKQRFKKK VSAALVIQKY
WRRALAKRKL LMLKKEKLER VHSKSASIIQ RYWRRYSTRK QFLKLKYYSI ILQSKIRMII
AVASYKRYHW ATVTIQXHWR AHVRSKQDRQ RYELLRSSTL VIQSAFRRWR RHKRQSQINA
AITLQRAFRE WRVQKRAQEE RAAVVIQSWY RMHRESQKYI HLRSCVIIIQ ARFRCFQAQK
LYTRTRESIL TLQKHYRAYV KGKVERTGYL QKRAAAIRLQ AAFRGRRARN LCKQIRAACV
LQSCWRMRQD RLRFLNLKKN IIRLQAHIRR RQQLQTYQKM KKAALVIQIH FRAYISAKEV
LASYQKTRSA VIVLQSACRR MQARKKFLHI LTAVVKIQSY YRAYASRRKF LRLKKATVKL
QSIVRMKQAR KQYLHLRAIA QQREEHLRAS CIKLQAFLRG YLVRKQVRLQ RKAAVLLQSY
FRMRKMRLEY LKVCQAAVVI QRYYRAHRAG AQQRKHFLQV RRAVTCLQAA YRGYKVRRQL
QQQSAAALKI QAAFRGYRQR TKYQSMLQSA LKIQRWYRTR KMVSALRSHF FKTRTAAISL
QSAYRGWKVR KQMRKEHEAA VKIQSAFRTA RAQKEFRLLK TAASVIQQHL RARATGLRQR
TEYMALRRAA VTLQSAWRGR AARRRIQKQQ RCAIIIQACY RRHVQWKRWE IMKKAARLIQ
MHYRAYRTGR KQHHLFLKTK GAAIILQSAF RGVRARKKVK EMHQAATTIQ SRYRAYQARK
KYASYRAAAV IIQRWYRAAK LAGCQREEYL AVKKAALKIQ AVYRGVRERR QTRRMHMAAT
LIKAAFKMQQ SRRRYQQMRT AAIVIQVRYR AYRQGRAQRA KYLTTLKAVA LLQAALRGAR
VRQNLRRMRT AATLIQAHYR GRRQQAYFNK LKKVTKTVQQ KYRAGRERHA QLRRYNQLRR
SAICIQAAFR GMRARKRLKA MHSAAAVIQR RFRTLVMRRR FLSLRKTAVW VQRKYRAKVC
ARHHLQQLQL QKAAIKIQSW YRGWMVRKKT QEMRRAATVL QAAFRRHRAR ARYQAWRRAS
QVIQQRFRAG QAARLQRRQY LQQXRSALVL QAAFRGMRIR RRLKRMHASA TLIQSRFRSV
RVRKRFLSLK KAAVFVQRKY RATICAKHHL QRFLELKKAI IIIQAFYRRR MVKKQLQEMH
RAAALIQASF RMHRARLAFQ TWKLAXVLIQ QHYRAYRAAK LQRALYIRWR HSAVVIQAAY
KGLKARQLLR EKHRAAVIIQ STYRMYRQHF SYQKLQWATK VIQERYRVSK RKALQHDALK
AAACARADFQ DMVIRGLIQE RQHQAAITVQ KHFRAFKTRK RYLHFRAKVV FVQRRYRVLM
AVRTQAAICI QSCFRGFKAR RGIQGMHLAA TRIQSCYRRH RARADYQAKK RAVVVIQNHY
RSYVRVKMER KEFLAIQKSA RTIQAAFRGM KVRQKLKTMP DEKMAAPATR PAFYCHRTES
QHEAGQSPAL VAQGLYKTSL VGPSQETEHH SQRKAAVTIQ KAFRKMVTRR LEKQRSAAVQ
IQSFLQMAVY RRRFLQQKRA ALTLQRYFRT QQSRKRFLLY REAAVGLQNP HRAFLPAKHQ
RELYSQIRSS VIIIQARVKG FIQKRKFRKL KDSTIKIQAV WRRHKARKYL REVKAACRIQ
AWYRCRKARK EYLAVLRAVR IIQRCFCTQQ QRRRFLNVRA SAVIIQRRWR AVLSGRTTHE
QSLMTKRHQA ACLIQANFRG YKARQVFLQQ KSAALTIQRF IRARKAGKHQ RMKYVELKKS
TVVLQALVRG WLVRKRISEQ RAKIRLLHFA AAAFYHLSAL RIQRAYRRHM ALKNANNKQL
NSAICIQRWF RARSQRKRFL QKYSIVNIQR EAREQASQHS RAASVIQRAV RHFLLRKKQE
NLNKRIAKIQ ALWRGYSWRK KNDTSKTKAI RQRLQCVNRE IREENKLYHR TVFALHHLLT
YKYLSTVLEA LKHLEAVTRL SSVCCEKMAQ SGAISKVFVL IRSCNRSVPC MEVIRYAVQV
LLNVAKYEKT TSAIYBVENC VDTLLELLQM YQEKSGDKVA DKSRSIFTKT CCLLAVLLKT
TTRASDVQSR SKVVDRIYSL YKLTAHKHKV NTERILCKQK KNSSVSLSFF PETPVRTRMV
SRLKPDWVLR RDNV
