ID   PDAD_HALSA              Reviewed;         160 AA.
AC   Q9HNQ0;
DT   11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Pyruvoyl-dependent arginine decarboxylase;
DE            Short=PvlArgDC;
DE            EC=4.1.1.19;
DE   Contains:
DE     RecName: Full=Pyruvoyl-dependent arginine decarboxylase subunit beta;
DE   Contains:
DE     RecName: Full=Pyruvoyl-dependent arginine decarboxylase subunit alpha;
GN   Name=pdaD; OrderedLocusNames=VNG_1999H;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:58145; EC=4.1.1.19;
CC   -!- COFACTOR:
CC       Name=pyruvate; Xref=ChEBI:CHEBI:15361; Evidence={ECO:0000250};
CC       Note=Binds 1 pyruvoyl group covalently per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the PdaD family. {ECO:0000305}.
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DR   EMBL; AE004437; AAG20170.1; -; Genomic_DNA.
DR   PIR; F84350; F84350.
DR   RefSeq; WP_010903471.1; NC_002607.1.
DR   AlphaFoldDB; Q9HNQ0; -.
DR   SMR; Q9HNQ0; -.
DR   STRING; 64091.VNG_1999H; -.
DR   PaxDb; Q9HNQ0; -.
DR   EnsemblBacteria; AAG20170; AAG20170; VNG_1999H.
DR   GeneID; 5953199; -.
DR   GeneID; 62887328; -.
DR   KEGG; hal:VNG_1999H; -.
DR   PATRIC; fig|64091.14.peg.1527; -.
DR   HOGENOM; CLU_134253_0_0_2; -.
DR   InParanoid; Q9HNQ0; -.
DR   OMA; TIRVVWG; -.
DR   OrthoDB; 100439at2157; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0008792; F:arginine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006527; P:arginine catabolic process; IEA:InterPro.
DR   Gene3D; 3.50.20.10; -; 1.
DR   InterPro; IPR016104; Pyr-dep_his/arg-deCO2ase.
DR   InterPro; IPR016105; Pyr-dep_his/arg-deCO2ase_sand.
DR   InterPro; IPR002724; Pyruvoyl-dep_arg_deCO2ase.
DR   PANTHER; PTHR40438; PTHR40438; 1.
DR   Pfam; PF01862; PvlArgDC; 1.
DR   PIRSF; PIRSF005216; Pyruvoyl-dep_arg_deCO2ase; 1.
DR   SFLD; SFLDG01170; Pyruvoyl-dependent_arginine_de; 1.
DR   SUPFAM; SSF56271; SSF56271; 1.
PE   3: Inferred from homology;
KW   Decarboxylase; Lyase; Pyruvate; Reference proteome.
FT   CHAIN           1..38
FT                   /note="Pyruvoyl-dependent arginine decarboxylase subunit
FT                   beta"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000023308"
FT   CHAIN           39..160
FT                   /note="Pyruvoyl-dependent arginine decarboxylase subunit
FT                   alpha"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000023309"
FT   SITE            38..39
FT                   /note="Cleavage (non-hydrolytic)"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         39
FT                   /note="Pyruvic acid (Ser)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   160 AA;  16364 MW;  B77749F3A1E97BCD CRC64;
     MPRIRIAWGS GVAPTEMAAY DAALADANVH NYNLIRVSSV IPADATVSPV DTAPDLGPAG
     NTLTVVEARG QTAGPGQASA GLAWAPRDGA PGLFYEAADE TTPDDVADRV TTGITAGMDV
     RDWDGVEPSV RTETVTADAG EHAAAVVIAA YGDSDPVFDQ