PDC10_CAEEL
ID PDC10_CAEEL Reviewed; 215 AA.
AC Q17958;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Programmed cell death protein 10 homolog {ECO:0000250|UniProtKB:Q8VE70};
DE AltName: Full=Cerebral cavernous malformation protein 3 {ECO:0000303|PubMed:25743393};
GN Name=ccm-3 {ECO:0000312|WormBase:C14A4.11};
GN ORFNames=C14A4.11 {ECO:0000312|WormBase:C14A4.11};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH GCK-1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=25743393; DOI=10.1038/ncomms7449;
RA Lant B., Yu B., Goudreault M., Holmyard D., Knight J.D., Xu P., Zhao L.,
RA Chin K., Wallace E., Zhen M., Gingras A.C., Derry W.B.;
RT "CCM-3/STRIPAK promotes seamless tube extension through endocytic
RT recycling.";
RL Nat. Commun. 6:6449-6449(2015).
CC -!- FUNCTION: Involved in excretory canal elongation during postembryonic
CC development. Plays a role in promoting Golgi stability, ER integrity
CC and vesicle transport probably by regulating the activation of Rho
CC GTPase cdc-42. Involved in fertility. {ECO:0000269|PubMed:25743393}.
CC -!- SUBUNIT: Interacts with gck-1. {ECO:0000269|PubMed:25743393}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25743393}. Apical
CC cell membrane {ECO:0000269|PubMed:25743393}; Peripheral membrane
CC protein {ECO:0000269|PubMed:25743393}. Note=Co-localizes with gck-1 at
CC the apical membrane of the excretory canals.
CC {ECO:0000269|PubMed:25743393}.
CC -!- TISSUE SPECIFICITY: Expressed in pharynx, intestine, germline, vulva
CC and excretory canals. {ECO:0000269|PubMed:25743393}.
CC -!- DISRUPTION PHENOTYPE: Animals are sterile and develop slowly. Excretory
CC canals are approximately 45% shorter and are characterized by a
CC discontinuous and wider lumen, the presence of cysts and an increased
CC number of canalicular vesicles which are swollen. These defects start
CC during the L3 larval stage and become more severe when reaching
CC adulthood. In addition, cdc-42 expression levels and activity are
CC reduced along the excretory canal length. Animals have also a reduced
CC distribution of Golgi and ER components along the excretory canals.
CC {ECO:0000269|PubMed:25743393}.
CC -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000305}.
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DR EMBL; BX284602; CAA90115.2; -; Genomic_DNA.
DR PIR; T19253; T19253.
DR RefSeq; NP_496290.2; NM_063889.5.
DR AlphaFoldDB; Q17958; -.
DR SMR; Q17958; -.
DR DIP; DIP-26279N; -.
DR IntAct; Q17958; 4.
DR STRING; 6239.C14A4.11.1; -.
DR EPD; Q17958; -.
DR PaxDb; Q17958; -.
DR PeptideAtlas; Q17958; -.
DR EnsemblMetazoa; C14A4.11.1; C14A4.11.1; WBGene00007561.
DR GeneID; 174638; -.
DR KEGG; cel:CELE_C14A4.11; -.
DR UCSC; C14A4.11; c. elegans.
DR CTD; 174638; -.
DR WormBase; C14A4.11; CE30598; WBGene00007561; ccm-3.
DR eggNOG; KOG4025; Eukaryota.
DR GeneTree; ENSGT00390000017913; -.
DR HOGENOM; CLU_083906_1_0_1; -.
DR InParanoid; Q17958; -.
DR OMA; HQTNMIM; -.
DR OrthoDB; 1507394at2759; -.
DR PhylomeDB; Q17958; -.
DR PRO; PR:Q17958; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00007561; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0098592; C:cytoplasmic side of apical plasma membrane; IDA:UniProtKB.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0035838; C:growing cell tip; IDA:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IMP:UniProtKB.
DR GO; GO:0060562; P:epithelial tube morphogenesis; IMP:UniProtKB.
DR GO; GO:2001137; P:positive regulation of endocytic recycling; IMP:UniProtKB.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IMP:UniProtKB.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:1903358; P:regulation of Golgi organization; IMP:UniProtKB.
DR InterPro; IPR009652; PDCD10.
DR PANTHER; PTHR13250; PTHR13250; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT CHAIN 1..215
FT /note="Programmed cell death protein 10 homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000433875"
SQ SEQUENCE 215 AA; 24769 MW; B6DF386B93859A53 CRC64;
MNEEGGYLGA MTYQCLYSPV MEKIKQQHRD DPRASLALNK LHTALTTCEQ ASPSFLYDFT
KVLLDDSELS VNLQESYLRM HDTSPTNDLI VSGYEQNADY KELTKRAIEL RRVLSRVPEE
MSDRHAFLET IKLIASSIKK LLEAINAVYR IVPLTAQPAV EKRKREFVHY SKRFSNTLKT
YFKDQNANQV SVSANQLVFQ TTMIVRTINE KLRRG
