PDC10_CHICK
ID PDC10_CHICK Reviewed; 212 AA.
AC Q5ZIV5;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Programmed cell death protein 10;
GN Name=PDCD10; ORFNames=RCJMB04_23e18;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways.
CC Increases mitogen-activated protein kinase activity. Important for cell
CC migration, and for normal structure and assembly of the Golgi complex.
CC Important for KDR/VEGFR2 signaling. Required for normal cardiovascular
CC development. Required for normal angiogenesis, vasculogenesis and
CC hematopoiesis during embryonic development.
CC {ECO:0000250|UniProtKB:Q8VE70, ECO:0000250|UniProtKB:Q9BUL8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000305}.
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DR EMBL; AJ720679; CAG32338.1; -; mRNA.
DR RefSeq; NP_001006554.1; NM_001006554.1.
DR RefSeq; XP_015147154.1; XM_015291668.1.
DR RefSeq; XP_015147155.1; XM_015291669.1.
DR AlphaFoldDB; Q5ZIV5; -.
DR SMR; Q5ZIV5; -.
DR BioGRID; 685310; 1.
DR IntAct; Q5ZIV5; 1.
DR STRING; 9031.ENSGALP00000041620; -.
DR PaxDb; Q5ZIV5; -.
DR Ensembl; ENSGALT00000015429; ENSGALP00000015413; ENSGALG00000009477.
DR Ensembl; ENSGALT00000091486; ENSGALP00000072696; ENSGALG00000009477.
DR GeneID; 425003; -.
DR KEGG; gga:425003; -.
DR CTD; 11235; -.
DR VEuPathDB; HostDB:geneid_425003; -.
DR eggNOG; KOG4025; Eukaryota.
DR GeneTree; ENSGT00390000017913; -.
DR HOGENOM; CLU_083906_1_0_1; -.
DR InParanoid; Q5ZIV5; -.
DR OMA; HVVLFPI; -.
DR OrthoDB; 1507394at2759; -.
DR PhylomeDB; Q5ZIV5; -.
DR TreeFam; TF105802; -.
DR PRO; PR:Q5ZIV5; -.
DR Proteomes; UP000000539; Chromosome 9.
DR Bgee; ENSGALG00000009477; Expressed in spermatocyte and 14 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0051683; P:establishment of Golgi localization; IEA:Ensembl.
DR GO; GO:0090168; P:Golgi reassembly; IEA:Ensembl.
DR GO; GO:0036481; P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl.
DR Gene3D; 1.10.12.70; -; 1.
DR InterPro; IPR046409; PDC10_dimerisation_sf.
DR InterPro; IPR009652; PDCD10.
DR PANTHER; PTHR13250; PTHR13250; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Apoptosis; Cell membrane; Cytoplasm; Golgi apparatus;
KW Membrane; Reference proteome.
FT CHAIN 1..212
FT /note="Programmed cell death protein 10"
FT /id="PRO_0000187565"
SQ SEQUENCE 212 AA; 24702 MW; 5AA7C88797B77A56 CRC64;
MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ
DIIMKILEKK SVDVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE
INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT
YFKDGKAINV FISANRLIHQ TNLILQTFKT VA
