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PDC10_RAT
ID   PDC10_RAT               Reviewed;         210 AA.
AC   Q6NX65;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Programmed cell death protein 10;
GN   Name=Pdcd10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20332113; DOI=10.1242/jcs.061341;
RA   Fidalgo M., Fraile M., Pires A., Force T., Pombo C., Zalvide J.;
RT   "CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell
RT   orientation.";
RL   J. Cell Sci. 123:1274-1284(2010).
CC   -!- FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways.
CC       Increases mitogen-activated protein kinase activity and STK26 activity.
CC       Important for cell migration, and for normal structure and assembly of
CC       the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the
CC       stability of KDR/VEGFR2 and prevents its breakdown. Required for normal
CC       cardiovascular development. Required for normal angiogenesis,
CC       vasculogenesis and hematopoiesis during embryonic development.
CC       {ECO:0000250|UniProtKB:Q8VE70, ECO:0000250|UniProtKB:Q9BUL8}.
CC   -!- SUBUNIT: Homodimer. Interacts (via C-terminus) with CCM2. Interacts
CC       (via C-terminus) with PXN. Interacts (via N-terminus) with STK25.
CC       Interacts (via N-terminus) with STK26. Interacts (via N-terminus) with
CC       STK24. Interacts with GOLGA2. Identified in a complex with KRIT1 and
CC       CCM2. Interacts with KDR/VEGFR2. Interaction with KDR/VEGFR2 is
CC       enhanced by stimulation with VEGFA. Interacts with RIPOR1 (via C-
CC       terminus); this interaction is required for the association of RIPOR1
CC       with either STK24 and STK26 kinases and occurs in a Rho-independent
CC       manner. {ECO:0000250|UniProtKB:Q9BUL8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000269|PubMed:20332113}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:20332113}; Cytoplasmic side
CC       {ECO:0000269|PubMed:20332113}. Cell membrane
CC       {ECO:0000269|PubMed:20332113}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:20332113}; Cytoplasmic side
CC       {ECO:0000269|PubMed:20332113}. Note=Partially colocalizes with
CC       endogenous PXN at the leading edges of migrating cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000305}.
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DR   EMBL; BC067245; AAH67245.1; -; mRNA.
DR   RefSeq; NP_001009542.1; NM_001009542.2.
DR   RefSeq; XP_006232563.1; XM_006232501.3.
DR   AlphaFoldDB; Q6NX65; -.
DR   SMR; Q6NX65; -.
DR   IntAct; Q6NX65; 1.
DR   STRING; 10116.ENSRNOP00000013585; -.
DR   jPOST; Q6NX65; -.
DR   PaxDb; Q6NX65; -.
DR   PRIDE; Q6NX65; -.
DR   DNASU; 494345; -.
DR   GeneID; 494345; -.
DR   KEGG; rno:494345; -.
DR   UCSC; RGD:1359329; rat.
DR   CTD; 11235; -.
DR   RGD; 1359329; Pdcd10.
DR   VEuPathDB; HostDB:ENSRNOG00000010147; -.
DR   eggNOG; KOG4025; Eukaryota.
DR   HOGENOM; CLU_083906_1_0_1; -.
DR   InParanoid; Q6NX65; -.
DR   OMA; HVVLFPI; -.
DR   OrthoDB; 1507394at2759; -.
DR   PhylomeDB; Q6NX65; -.
DR   TreeFam; TF105802; -.
DR   PRO; PR:Q6NX65; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000010147; Expressed in duodenum and 20 other tissues.
DR   Genevisible; Q6NX65; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0047485; F:protein N-terminus binding; ISO:RGD.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; ISO:RGD.
DR   GO; GO:0051683; P:establishment of Golgi localization; ISO:RGD.
DR   GO; GO:0090168; P:Golgi reassembly; ISO:RGD.
DR   GO; GO:0036481; P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide; ISO:RGD.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; ISO:RGD.
DR   GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISO:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0090316; P:positive regulation of intracellular protein transport; ISO:RGD.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISO:RGD.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR   GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISO:RGD.
DR   GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISO:RGD.
DR   GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR   GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR   GO; GO:0042542; P:response to hydrogen peroxide; ISO:RGD.
DR   GO; GO:0044319; P:wound healing, spreading of cells; ISO:RGD.
DR   Gene3D; 1.10.12.70; -; 1.
DR   InterPro; IPR046409; PDC10_dimerisation_sf.
DR   InterPro; IPR009652; PDCD10.
DR   PANTHER; PTHR13250; PTHR13250; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Angiogenesis; Apoptosis; Cell membrane; Cytoplasm;
KW   Golgi apparatus; Isopeptide bond; Membrane; Reference proteome;
KW   Ubl conjugation.
FT   CHAIN           1..210
FT                   /note="Programmed cell death protein 10"
FT                   /id="PRO_0000187564"
FT   MOD_RES         177
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUL8"
FT   CROSSLNK        184
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BUL8"
SQ   SEQUENCE   210 AA;  24355 MW;  3382E1B3C0877DBF CRC64;
     MTMEEMKTEA EAASMVSMPL YAVMYPVFNE LERVNLSAAQ TLRAAFIKAE KENPGLTQDI
     IMKILEKKSV EVNFTESLLR MAADDVEEYM IERPEPEFQD LNEKARALKQ ILSKIPDEIN
     DRVRFLQTIK DIASAIKELL DTVNNVFKKY QYQNRRALEH QKKEFVKYSK SFSDTLKTYF
     KDGKAINVFI SANRLIHQTN LILQTFKTVA
 
 
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