ID   PDC10_XENTR             Reviewed;         212 AA.
AC   Q6DF07;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Programmed cell death protein 10;
GN   Name=pdcd10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways.
CC       Increases mitogen-activated protein kinase activity. Important for cell
CC       migration, and for normal structure and assembly of the Golgi complex.
CC       Important for KDR/VEGFR2 signaling. Required for normal cardiovascular
CC       development. Required for normal angiogenesis, vasculogenesis and
CC       hematopoiesis during embryonic development.
CC       {ECO:0000250|UniProtKB:Q8VE70, ECO:0000250|UniProtKB:Q9BUL8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDCD10 family. {ECO:0000305}.
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DR   EMBL; BC076936; AAH76936.1; -; mRNA.
DR   RefSeq; NP_001006850.1; NM_001006849.1.
DR   RefSeq; XP_012818346.1; XM_012962892.1.
DR   AlphaFoldDB; Q6DF07; -.
DR   SMR; Q6DF07; -.
DR   STRING; 8364.ENSXETP00000049474; -.
DR   DNASU; 448600; -.
DR   GeneID; 448600; -.
DR   KEGG; xtr:448600; -.
DR   CTD; 11235; -.
DR   Xenbase; XB-GENE-1010361; pdcd10.
DR   eggNOG; KOG4025; Eukaryota.
DR   InParanoid; Q6DF07; -.
DR   OrthoDB; 1507394at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022875; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR   GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central.
DR   Gene3D; 1.10.12.70; -; 1.
DR   InterPro; IPR046409; PDC10_dimerisation_sf.
DR   InterPro; IPR009652; PDCD10.
DR   PANTHER; PTHR13250; PTHR13250; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Apoptosis; Cell membrane; Cytoplasm; Golgi apparatus;
KW   Membrane; Reference proteome.
FT   CHAIN           1..212
FT                   /note="Programmed cell death protein 10"
FT                   /id="PRO_0000187568"
SQ   SEQUENCE   212 AA;  24666 MW;  615453DB8D4259C8 CRC64;
     MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELEHVNLSA AQTLRAAFIK AEKENPGLTQ
     DIITKILEKK SVEVNFTESL LRMAADDVEE YMVERPEPEF QELNEKARAL KQILSKIPDE
     INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT
     YFKDGKALNV FISANRLIHQ TNLILQTFKT VA