ID   PDCD2_BOVIN             Reviewed;         344 AA.
AC   Q2YDC9;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Programmed cell death protein 2;
GN   Name=PDCD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a DNA-binding protein with a regulatory function. May
CC       play an important role in cell death and/or in regulation of cell
CC       proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- PTM: Ubiquitinated by PRKN, promoting proteasomal degradation.
CC       {ECO:0000250}.
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DR   EMBL; BC110283; AAI10284.1; -; mRNA.
DR   RefSeq; NP_001039574.1; NM_001046109.2.
DR   AlphaFoldDB; Q2YDC9; -.
DR   STRING; 9913.ENSBTAP00000014845; -.
DR   PaxDb; Q2YDC9; -.
DR   PRIDE; Q2YDC9; -.
DR   Ensembl; ENSBTAT00000014845; ENSBTAP00000014845; ENSBTAG00000011179.
DR   GeneID; 512079; -.
DR   KEGG; bta:512079; -.
DR   CTD; 5134; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011179; -.
DR   VGNC; VGNC:32660; PDCD2.
DR   eggNOG; KOG2061; Eukaryota.
DR   GeneTree; ENSGT00940000156603; -.
DR   HOGENOM; CLU_034893_2_0_1; -.
DR   InParanoid; Q2YDC9; -.
DR   OMA; ENLDWGV; -.
DR   OrthoDB; 1181470at2759; -.
DR   TreeFam; TF313722; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000011179; Expressed in oocyte and 112 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
DR   GO; GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   InterPro; IPR007320; PDCD2_C.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF04194; PDCD2_C; 1.
DR   Pfam; PF01753; zf-MYND; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
DR   PROSITE; PS50865; ZF_MYND_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..344
FT                   /note="Programmed cell death protein 2"
FT                   /id="PRO_0000290033"
FT   ZN_FING         135..172
FT                   /note="MYND-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         135
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         146
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         149
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         155
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         159
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         168
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT   BINDING         172
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
SQ   SEQUENCE   344 AA;  38687 MW;  006A65D216F1009D CRC64;
     MASESAGPAE LGFVEAAPSW RLRSEQFPSK VGGRPAWLSA AGLPGPPELA CPLCGRPMAF
     LLQVYAPLPG RADAFHRCLF LFCCRTPPCC CGLRVFRNQL PRQNDFYSYE PPSEDPPSET
     GESVYLHLKS GAHLCRVCGC SGPKRCSRCH KAHYCSKEHQ SLDWRLGHKQ ACAQTDNLDN
     IVPDHNFLFP EFEIVIETED EIMPEVVERD DESEIIGTMG EAHEEELESM AKHESKEDRI
     FRKFKTKISL EPEQILRYGR GIAPLWISGE NTPKEKDIPD CPCGAKRLFE FQVMPQLLNY
     LKADRLGRSV DWGVLAIFTC AESCKLGIGY TEEFVWKQDI TDAA