PDCD2_MOUSE
ID PDCD2_MOUSE Reviewed; 343 AA.
AC P46718; Q8BR06;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Programmed cell death protein 2;
DE AltName: Full=Zinc finger protein Rp-8;
GN Name=Pdcd2; Synonyms=Rp8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Thymus;
RX PubMed=7880439; DOI=10.1089/dna.1995.14.189;
RA Vaux D.L., Haecker G.;
RT "Cloning of mouse RP-8 cDNA and its expression during apoptosis of lymphoid
RT and myeloid cells.";
RL DNA Cell Biol. 14:189-193(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be a DNA-binding protein with a regulatory function. May
CC play an important role in cell death and/or in regulation of cell
CC proliferation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during apoptosis of lymphoid and myeloid
CC cells.
CC -!- PTM: Ubiquitinated by PRKN, promoting proteasomal degradation.
CC {ECO:0000250}.
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DR EMBL; U10903; AAA83433.1; -; mRNA.
DR EMBL; AK045985; BAC32560.1; -; mRNA.
DR CCDS; CCDS28413.1; -.
DR PIR; I49067; I49067.
DR RefSeq; NP_032825.2; NM_008799.2.
DR AlphaFoldDB; P46718; -.
DR IntAct; P46718; 1.
DR STRING; 10090.ENSMUSP00000052523; -.
DR PhosphoSitePlus; P46718; -.
DR EPD; P46718; -.
DR MaxQB; P46718; -.
DR PaxDb; P46718; -.
DR PeptideAtlas; P46718; -.
DR PRIDE; P46718; -.
DR ProteomicsDB; 287900; -.
DR DNASU; 18567; -.
DR GeneID; 18567; -.
DR KEGG; mmu:18567; -.
DR UCSC; uc008aoq.1; mouse.
DR CTD; 5134; -.
DR MGI; MGI:104643; Pdcd2.
DR eggNOG; KOG2061; Eukaryota.
DR InParanoid; P46718; -.
DR OrthoDB; 1181470at2759; -.
DR PhylomeDB; P46718; -.
DR TreeFam; TF313722; -.
DR BioGRID-ORCS; 18567; 13 hits in 44 CRISPR screens.
DR ChiTaRS; Pdcd2; mouse.
DR PRO; PR:P46718; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P46718; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; ISO:MGI.
DR GO; GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISO:MGI.
DR InterPro; IPR007320; PDCD2_C.
DR InterPro; IPR002893; Znf_MYND.
DR Pfam; PF04194; PDCD2_C; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..343
FT /note="Programmed cell death protein 2"
FT /id="PRO_0000218305"
FT ZN_FING 134..171
FT /note="MYND-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 134
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 145
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 148
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 154
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 167
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 171
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT CONFLICT 88
FT /note="L -> P (in Ref. 2; BAC32560)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="A -> P (in Ref. 1; AAA83433)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 38342 MW; 6D67243B0EA16BAC CRC64;
MAAAAPGPVE LGFAEEAPAW RLRSEQFPSK VGGRPAWLGL AELPGPGALA CARCGRPLAF
LLQVYAPLPG RDDAFHRSLF LFCCREPLCC AGLRVFRNQL PRNNAFYSYE PPSETEALGT
ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ AHYCSKEHQT LDWRLGHKQA CTQSDKIDHM
VPDHNFLFPE FEIVTETEDE ILPEVVEMED YSEVTGSMGG IPEEELDSMA KHESKEDHIF
QKFKSKIALE PEQILRYGRG IKPIWISGEN IPQEKDIPDC PCGAKRIFEF QVMPQLLNHL
KADRLGRSID WGVLAVFTCA ESCSLGSGYT EEFVWKQDVT DTP
