PDCD2_RAT
ID PDCD2_RAT Reviewed; 343 AA.
AC P47816; G3V666;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Programmed cell death protein 2;
DE AltName: Full=Zinc finger protein Rp-8;
GN Name=Pdcd2; Synonyms=Rp8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 57-343.
RC STRAIN=Sprague-Dawley; TISSUE=Thymus;
RX PubMed=2072913; DOI=10.1128/mcb.11.8.4177-4188.1991;
RA Owens G.P., Hahn W.E., Cohen J.J.;
RT "Identification of mRNAs associated with programmed cell death in immature
RT thymocytes.";
RL Mol. Cell. Biol. 11:4177-4188(1991).
CC -!- FUNCTION: May be a DNA-binding protein with a regulatory function. May
CC play an important role in cell death and/or in regulation of cell
CC proliferation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during apoptosis.
CC -!- INDUCTION: By irradiation and dexamethasone.
CC -!- PTM: Ubiquitinated by PRKN, promoting proteasomal degradation.
CC {ECO:0000250}.
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DR EMBL; CH474033; EDL99815.1; -; Genomic_DNA.
DR EMBL; M80601; AAA42067.1; -; mRNA.
DR PIR; A41257; A41257.
DR RefSeq; NP_113826.1; NM_031638.1.
DR AlphaFoldDB; P47816; -.
DR STRING; 10116.ENSRNOP00000002040; -.
DR jPOST; P47816; -.
DR PaxDb; P47816; -.
DR PRIDE; P47816; -.
DR Ensembl; ENSRNOT00000002040; ENSRNOP00000002040; ENSRNOG00000001490.
DR GeneID; 58934; -.
DR KEGG; rno:58934; -.
DR CTD; 5134; -.
DR RGD; 61887; Pdcd2.
DR eggNOG; KOG2061; Eukaryota.
DR GeneTree; ENSGT00940000156603; -.
DR HOGENOM; CLU_034893_2_0_1; -.
DR InParanoid; P47816; -.
DR OMA; ENLDWGV; -.
DR OrthoDB; 1181470at2759; -.
DR TreeFam; TF313722; -.
DR PRO; PR:P47816; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Proteomes; UP000234681; Chromosome 1.
DR Bgee; ENSRNOG00000001490; Expressed in thymus and 20 other tissues.
DR Genevisible; P47816; RN.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:RGD.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; ISO:RGD.
DR GO; GO:0012501; P:programmed cell death; IEP:RGD.
DR GO; GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; ISO:RGD.
DR InterPro; IPR007320; PDCD2_C.
DR InterPro; IPR002893; Znf_MYND.
DR Pfam; PF04194; PDCD2_C; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..343
FT /note="Programmed cell death protein 2"
FT /id="PRO_0000218306"
FT ZN_FING 134..171
FT /note="MYND-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 134
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 137
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 145
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 148
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 154
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 167
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT BINDING 171
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00134"
FT CONFLICT 73
FT /note="E -> D (in Ref. 3; AAA42067)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="F -> L (in Ref. 3; AAA42067)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="A -> V (in Ref. 3; AAA42067)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="Y -> F (in Ref. 3; AAA42067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 38444 MW; 94A4B9540ABFD9A9 CRC64;
MAAVVPVTVE LGFVEEAPAW RLRSEQFPSK VGGRPAWLAL AELPGPGALA CARCGRPLAF
LLQVYAPLPG RDEAFHRSLF LFCCREPLCC AGLRVFRNQL PRKNAFYSYE PPSETGASDT
ECVCLQLKSG AHLCRVCGCL APMTCSRCKQ AHYCSKEHQT LDWQLGHKQA CTQSDHLDHM
VPDHNFLFPE FEIVTETEDE IGPEVVEMED YSEVIGSMEG VPEEELDSMA KHESKEDHIF
QKFKSKIALE PEQILRYGRG IKPIWISGEN IPQEKDIPDC SCGAKRIFEF QVMPQLLNHL
KADRLGTSVD WGILAVFTCA ESCSLGIGYT EEFVWKQDVT ETP
