ID   PDCD4_CHICK             Reviewed;         467 AA.
AC   Q98TX3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Programmed cell death protein 4;
DE   AltName: Full=Protein I11/6;
GN   Name=PDCD4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=11313950; DOI=10.1038/sj.onc.1204071;
RA   Schlichter U., Burk O., Worpenberg S., Klempnauer K.-H.;
RT   "The chicken Pdcd4 gene is regulated by v-Myb.";
RL   Oncogene 20:231-239(2001).
CC   -!- FUNCTION: Inhibits translation initiation and cap-dependent
CC       translation. May excert its function by hindering the interaction
CC       between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds
CC       RNA (By similarity). Does not seem to be involved in apoptosis.
CC       {ECO:0000250, ECO:0000269|PubMed:11313950}.
CC   -!- SUBUNIT: Interacts with EIF4A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11313950}. Cytoplasm
CC       {ECO:0000269|PubMed:11313950}. Note=Shuttles between the nucleus and
CC       cytoplasm. Predominantly nuclear under normal growth conditions.
CC   -!- TISSUE SPECIFICITY: Expressed in a broad spectrum of hematopoietic
CC       organs, such as thymus and bursa. Lower levels of expression detected
CC       in the kidney. {ECO:0000269|PubMed:11313950}.
CC   -!- INDUCTION: Up-regulated by viral v-myb. {ECO:0000269|PubMed:11313950}.
CC   -!- SIMILARITY: Belongs to the PDCD4 family. {ECO:0000305}.
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DR   EMBL; AF321288; AAK09354.1; -; mRNA.
DR   RefSeq; NP_989635.1; NM_204304.1.
DR   AlphaFoldDB; Q98TX3; -.
DR   SMR; Q98TX3; -.
DR   STRING; 9031.ENSGALP00000014143; -.
DR   PaxDb; Q98TX3; -.
DR   GeneID; 374191; -.
DR   KEGG; gga:374191; -.
DR   CTD; 27250; -.
DR   VEuPathDB; HostDB:geneid_374191; -.
DR   eggNOG; KOG0403; Eukaryota.
DR   InParanoid; Q98TX3; -.
DR   OrthoDB; 434771at2759; -.
DR   PhylomeDB; Q98TX3; -.
DR   PRO; PR:Q98TX3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IMP:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0043508; P:negative regulation of JUN kinase activity; IDA:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR039778; PDCD4.
DR   PANTHER; PTHR12626; PTHR12626; 1.
DR   Pfam; PF02847; MA3; 2.
DR   SMART; SM00544; MA3; 2.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS51366; MI; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..467
FT                   /note="Programmed cell death protein 4"
FT                   /id="PRO_0000256523"
FT   DOMAIN          161..282
FT                   /note="MI 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   DOMAIN          324..447
FT                   /note="MI 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   REGION          21..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          57..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           57..63
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           446..452
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   467 AA;  51708 MW;  361B04FFA47B99E8 CRC64;
     MEIEKQHVYI STVEVENLSD ALFSGDEENG GSEERKTEIN GNWIPATSIT EAKINAKAKR
     RLRKNSSRDS GRGDSVSENG ETQKAGLVVP TSPKGKVLDR RSRSGKGRGL PKKGGAGGKG
     VWGTPGQVYD VEEVDIKDPN YDDDQENCVY ETVVLPLDER AFEKTLTPII QEYFEHGDTN
     EVSEMLKDLN LGEMKYSVPV LAVSLALEGK ASHREMTSKL ISDLCGTVVS KTDVEKSFDK
     LLKDLPDLVL DSPRAPQLVG QFIARAVGDG ILSSTYIDGY KGTVDSIQAR AALDRATVLL
     SVTKGGKRID NVWGSGGGQQ SVKHLVKEID MLLKEYLLSG DLLEAERCLQ ELEVPHFHHE
     LVYEAIVMVL ESTGEKTFKM MLDLLKSLSR SSVITMDQMK RGYERVYCEI PDINLDVPHS
     YSVLERFVEE CFQAGIISKP LRDLCPSRGR KRFVSEGDGG RLKPESY