PDCD5_MOUSE
ID PDCD5_MOUSE Reviewed; 126 AA.
AC P56812;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Programmed cell death protein 5;
DE AltName: Full=TF-1 cell apoptosis-related protein 19;
DE Short=Protein TFAR19;
GN Name=Pdcd5; Synonyms=Tfar19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Heart;
RX PubMed=9920759; DOI=10.1006/bbrc.1998.9893;
RA Liu H.T., Wang Y.G., Zhang Y.M., Song Q.S., Di C.H., Chen G., Tang J.,
RA Ma D.L.;
RT "TFAR19, a novel apoptosis-related gene cloned from human leukemia cell
RT line TF-1, could enhance apoptosis of some tumor cells induced by growth
RT factor withdrawal.";
RL Biochem. Biophys. Res. Commun. 254:203-210(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May function in the process of apoptosis. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:9920759}.
CC -!- SIMILARITY: Belongs to the PDCD5 family. {ECO:0000305}.
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DR EMBL; AF161074; AAD45607.1; -; mRNA.
DR EMBL; BC048476; AAH48476.1; -; mRNA.
DR EMBL; BC056167; AAH56167.1; -; mRNA.
DR CCDS; CCDS52203.1; -.
DR RefSeq; NP_062720.1; NM_019746.4.
DR RefSeq; XP_001478306.1; XM_001478256.5.
DR AlphaFoldDB; P56812; -.
DR SMR; P56812; -.
DR STRING; 10090.ENSMUSP00000113761; -.
DR iPTMnet; P56812; -.
DR PhosphoSitePlus; P56812; -.
DR CPTAC; non-CPTAC-3853; -.
DR EPD; P56812; -.
DR jPOST; P56812; -.
DR PaxDb; P56812; -.
DR PeptideAtlas; P56812; -.
DR PRIDE; P56812; -.
DR ProteomicsDB; 288012; -.
DR TopDownProteomics; P56812; -.
DR Antibodypedia; 15598; 248 antibodies from 31 providers.
DR DNASU; 56330; -.
DR Ensembl; ENSMUST00000118501; ENSMUSP00000113761; ENSMUSG00000030417.
DR GeneID; 56330; -.
DR KEGG; mmu:56330; -.
DR UCSC; uc009gkf.1; mouse.
DR CTD; 9141; -.
DR MGI; MGI:1913538; Pdcd5.
DR VEuPathDB; HostDB:ENSMUSG00000030417; -.
DR eggNOG; KOG3431; Eukaryota.
DR GeneTree; ENSGT00390000011085; -.
DR HOGENOM; CLU_122978_4_0_1; -.
DR InParanoid; P56812; -.
DR OMA; KPQFGEQ; -.
DR OrthoDB; 1645187at2759; -.
DR PhylomeDB; P56812; -.
DR TreeFam; TF313112; -.
DR BioGRID-ORCS; 56330; 10 hits in 74 CRISPR screens.
DR ChiTaRS; Pdcd5; mouse.
DR PRO; PR:P56812; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P56812; protein.
DR Bgee; ENSMUSG00000030417; Expressed in myocardium of ventricle and 126 other tissues.
DR ExpressionAtlas; P56812; baseline and differential.
DR Genevisible; P56812; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0010698; F:acetyltransferase activator activity; ISO:MGI.
DR GO; GO:0048487; F:beta-tubulin binding; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; ISO:MGI.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:1903645; P:negative regulation of chaperone-mediated protein folding; ISO:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:1903638; P:positive regulation of protein insertion into mitochondrial outer membrane; ISO:MGI.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISO:MGI.
DR Gene3D; 1.10.8.140; -; 1.
DR InterPro; IPR002836; PDCD5-like.
DR InterPro; IPR036883; PDCD5-like_sf.
DR PANTHER; PTHR10840; PTHR10840; 1.
DR Pfam; PF01984; dsDNA_bind; 1.
DR PIRSF; PIRSF015730; TFAR19; 1.
DR SUPFAM; SSF46950; SSF46950; 1.
PE 1: Evidence at protein level;
KW Acetylation; Apoptosis; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O14737"
FT CHAIN 2..126
FT /note="Programmed cell death protein 5"
FT /id="PRO_0000121546"
FT REGION 17..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O14737"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14737"
FT MOD_RES 63
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:O14737"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747,
FT ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:21183079"
SQ SEQUENCE 126 AA; 14275 MW; 05796820CD5C780B CRC64;
MADEELEALR KQRLAELQAK HGDPGDAAQQ EAKQREAEMR NSILAQVLDQ SARARLSNLA
LVKPEKTKAV ENYLIQMARY GQLSGKVSEQ GLIEILEKVS QQTEKKTTVK FNRRKVMDSD
EDDADY
