PDCD7_HUMAN
ID PDCD7_HUMAN Reviewed; 485 AA.
AC Q8N8D1; Q96AK8; Q9Y6D7;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Programmed cell death protein 7;
DE AltName: Full=ES18;
DE Short=hES18;
GN Name=PDCD7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 269-485.
RC TISSUE=Thymus;
RX PubMed=10037816; DOI=10.1093/nar/27.6.1524;
RA Park E.J., Kim J.H., Seong R.H., Kim C.G., Park S.D., Hong S.H.;
RT "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell
RT death of T-cells.";
RL Nucleic Acids Res. 27:1524-1530(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-485.
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-485.
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15146077; DOI=10.1261/rna.7320604;
RA Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S.,
RA Tuschl T., Luehrmann R.;
RT "The human 18S U11/U12 snRNP contains a set of novel proteins not found in
RT the U2-dependent spliceosome.";
RL RNA 10:929-941(2004).
RN [6]
RP INTERACTION WITH RBM40.
RX PubMed=16096647; DOI=10.1038/sj.emboj.7600765;
RA Benecke H., Luehrmann R., Will C.L.;
RT "The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12
RT snRNA and U11-59K protein.";
RL EMBO J. 24:3057-3069(2005).
CC -!- FUNCTION: Promotes apoptosis when overexpressed. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RBM40. Component of the U11/U12 snRNPs that are
CC part of the U12-type spliceosome. {ECO:0000269|PubMed:15146077,
CC ECO:0000269|PubMed:16096647}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AK096970; BAC04915.1; -; mRNA.
DR EMBL; AF083930; AAD20241.1; -; mRNA.
DR EMBL; BC016992; AAH16992.2; -; mRNA.
DR EMBL; BT007395; AAP36059.1; -; mRNA.
DR CCDS; CCDS10201.1; -.
DR RefSeq; NP_005698.1; NM_005707.1.
DR AlphaFoldDB; Q8N8D1; -.
DR SMR; Q8N8D1; -.
DR BioGRID; 115390; 64.
DR CORUM; Q8N8D1; -.
DR IntAct; Q8N8D1; 21.
DR MINT; Q8N8D1; -.
DR STRING; 9606.ENSP00000204549; -.
DR iPTMnet; Q8N8D1; -.
DR MetOSite; Q8N8D1; -.
DR PhosphoSitePlus; Q8N8D1; -.
DR BioMuta; PDCD7; -.
DR DMDM; 38258174; -.
DR EPD; Q8N8D1; -.
DR jPOST; Q8N8D1; -.
DR MassIVE; Q8N8D1; -.
DR MaxQB; Q8N8D1; -.
DR PaxDb; Q8N8D1; -.
DR PeptideAtlas; Q8N8D1; -.
DR PRIDE; Q8N8D1; -.
DR ProteomicsDB; 72402; -.
DR Antibodypedia; 25914; 246 antibodies from 30 providers.
DR DNASU; 10081; -.
DR Ensembl; ENST00000204549.9; ENSP00000204549.4; ENSG00000090470.15.
DR GeneID; 10081; -.
DR KEGG; hsa:10081; -.
DR MANE-Select; ENST00000204549.9; ENSP00000204549.4; NM_005707.2; NP_005698.1.
DR UCSC; uc002aol.3; human.
DR CTD; 10081; -.
DR DisGeNET; 10081; -.
DR GeneCards; PDCD7; -.
DR HGNC; HGNC:8767; PDCD7.
DR HPA; ENSG00000090470; Low tissue specificity.
DR MIM; 608138; gene.
DR neXtProt; NX_Q8N8D1; -.
DR OpenTargets; ENSG00000090470; -.
DR PharmGKB; PA33117; -.
DR VEuPathDB; HostDB:ENSG00000090470; -.
DR eggNOG; ENOG502QQNP; Eukaryota.
DR GeneTree; ENSGT00390000017392; -.
DR HOGENOM; CLU_027959_0_0_1; -.
DR InParanoid; Q8N8D1; -.
DR OMA; PPWSSRW; -.
DR OrthoDB; 1097362at2759; -.
DR PhylomeDB; Q8N8D1; -.
DR TreeFam; TF332996; -.
DR PathwayCommons; Q8N8D1; -.
DR Reactome; R-HSA-72165; mRNA Splicing - Minor Pathway.
DR SignaLink; Q8N8D1; -.
DR BioGRID-ORCS; 10081; 590 hits in 1083 CRISPR screens.
DR ChiTaRS; PDCD7; human.
DR GeneWiki; PDCD7; -.
DR GenomeRNAi; 10081; -.
DR Pharos; Q8N8D1; Tbio.
DR PRO; PR:Q8N8D1; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q8N8D1; protein.
DR Bgee; ENSG00000090470; Expressed in secondary oocyte and 196 other tissues.
DR ExpressionAtlas; Q8N8D1; baseline and differential.
DR Genevisible; Q8N8D1; HS.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IDA:HGNC-UCL.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0051384; P:response to glucocorticoid; ISS:HGNC-UCL.
DR GO; GO:0008380; P:RNA splicing; IC:HGNC-UCL.
DR InterPro; IPR031974; PDCD7.
DR Pfam; PF16021; PDCD7; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Coiled coil; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..485
FT /note="Programmed cell death protein 7"
FT /id="PRO_0000058269"
FT REGION 1..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 232..335
FT /evidence="ECO:0000255"
FT COILED 362..411
FT /evidence="ECO:0000255"
FT COMPBIAS 8..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..130
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 292
FT /note="Q -> GE (in Ref. 2; AAD20241)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="S -> A (in Ref. 2; AAD20241)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 54700 MW; FF907D6D2187832A CRC64;
MALPPFFGQG RPGPPPPQPP PPAPFGCPPP PLPSPAFPPP LPQRPGPFPG ASAPFLQPPL
ALQPRASAEA SRGGGGAGAF YPVPPPPLPP PPPQCRPFPG TDAGERPRPP PPGPGPPWSP
RWPEAPPPPA DVLGDAALQR LRDRQWLEAV FGTPRRAGCP VPQRTHAGPS LGEVRARLLR
ALRLVRRLRG LSQALREAEA DGAAWVLLYS QTAPLRAELA ERLQPLTQAA YVGEARRRLE
RVRRRRLRLR ERAREREAER EAEAARAVER EQEIDRWRVK CVQEVEEKKR EQELKAAADG
VLSEVRKKQA DTKRMVDILR ALEKLRKLRK EAAARKGVCP PASADETFTH HLQRLRKLIK
KRSELYEAEE RALRVMLEGE QEEERKRELE KKQRKEKEKI LLQKREIESK LFGDPDEFPL
AHLLEPFRQY YLQAEHSLPA LIQIRHDWDQ YLVPSDHPKG NFVPQGWVLP PLPSNDIWAT
AVKLH
