ID   PDCD7_MOUSE             Reviewed;         482 AA.
AC   Q9WTY1; Q8R5D9;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Programmed cell death protein 7;
DE   AltName: Full=ES18;
GN   Name=Pdcd7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryonic stem cell, and Thymus;
RX   PubMed=10037816; DOI=10.1093/nar/27.6.1524;
RA   Park E.J., Kim J.H., Seong R.H., Kim C.G., Park S.D., Hong S.H.;
RT   "Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell
RT   death of T-cells.";
RL   Nucleic Acids Res. 27:1524-1530(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 164-176, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (APR-2007) to UniProtKB.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-482.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=10087507; DOI=10.3109/09687689709044322;
RA   Ritzel M.W.L., Yao S.Y.M., Ng A.M.L., Mackey J.R., Cass C.E., Young J.D.;
RT   "Molecular cloning, functional expression and chromosomal localization of a
RT   cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for
RT   purine nucleosides and uridine.";
RL   Mol. Membr. Biol. 15:203-211(1998).
CC   -!- FUNCTION: Promotes apoptosis when overexpressed.
CC       {ECO:0000269|PubMed:10087507}.
CC   -!- SUBUNIT: Interacts with RBM40. Component of the U11/U12 snRNPs that are
CC       part of the U12-type spliceosome (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis, thymus and lymph nodes.
CC       Detected at low levels in embryonic stem cells.
CC   -!- INDUCTION: Upon induction of apoptosis in embryonic stem cells by
CC       treatment with dexamethasone, staurosporine or C2-ceramide.
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DR   EMBL; AF083929; AAD20240.1; -; mRNA.
DR   EMBL; BC022772; AAH22772.2; -; mRNA.
DR   AlphaFoldDB; Q9WTY1; -.
DR   SMR; Q9WTY1; -.
DR   STRING; 10090.ENSMUSP00000035515; -.
DR   iPTMnet; Q9WTY1; -.
DR   PhosphoSitePlus; Q9WTY1; -.
DR   EPD; Q9WTY1; -.
DR   MaxQB; Q9WTY1; -.
DR   PRIDE; Q9WTY1; -.
DR   ProteomicsDB; 301778; -.
DR   MGI; MGI:1859170; Pdcd7.
DR   eggNOG; ENOG502QQNP; Eukaryota.
DR   InParanoid; Q9WTY1; -.
DR   PhylomeDB; Q9WTY1; -.
DR   Reactome; R-MMU-72165; mRNA Splicing - Minor Pathway.
DR   ChiTaRS; Pdcd7; mouse.
DR   PRO; PR:Q9WTY1; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9WTY1; protein.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; ISS:HGNC-UCL.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:MGI.
DR   GO; GO:0070234; P:positive regulation of T cell apoptotic process; IDA:MGI.
DR   GO; GO:0051384; P:response to glucocorticoid; IDA:HGNC-UCL.
DR   InterPro; IPR031974; PDCD7.
DR   Pfam; PF16021; PDCD7; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Coiled coil; Direct protein sequencing; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..482
FT                   /note="Programmed cell death protein 7"
FT                   /id="PRO_0000058270"
FT   REGION          1..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          233..408
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..54
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..127
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  54357 MW;  622E986F177C00A1 CRC64;
     MALPPFFAQS RQGPPPPQPP PSAPFGCPPP PLPSPAFPPP LPQRPGPFPG ASAPFLQPPL
     ALQPRAPAEA SRGGGGGGAF FPVPPPPLPP PPPQCRPFPG PDAVERPRPP PPGPGPPWSP
     RWAEAPPPPD VLGDAALQRL RDRQWLEAVF GNPRRPGGLR TPRTPAGPSL GEVRARLRSA
     LRLVRRLRSL GQSLREAEAD GAAWASLHAQ AAPLRAELAE RLQPLRQAAY VGEARRRLER
     VRRRVRVRER ARDRRLSGRR GAQRTEREQE IDRWRVKCVQ EVEEKKRDEE LKAAADGVLA
     EVRKKQSDTK RMVDILRALE KLRKLRKEAA ARKGVCPPAS ADETFEHHLQ RLRKLIKKRS
     ELYEAEERAL RVMLEGEQEE ERRRELEKKQ RKEKEKLLLQ KREIESKLFG DPDEFPLAHL
     LQPFRQYYLQ AEHSLPALIQ IRHDWDQYLV PSDHPKGNSV PQGWVLPPLP SNDIWATAIQ
     LH