PDCL2_HUMAN
ID PDCL2_HUMAN Reviewed; 241 AA.
AC Q8N4E4; A8MWA2; B9ZVQ9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Phosducin-like protein 2;
GN Name=PDCL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 88-205.
RX PubMed=19193988; DOI=10.1107/s1744309108037342;
RA Lou X., Bao R., Zhou C.Z., Chen Y.;
RT "Structure of the thioredoxin-fold domain of human phosducin-like protein
RT 2.";
RL Acta Crystallogr. F 65:67-70(2009).
CC -!- SIMILARITY: Belongs to the phosducin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH34431.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC024243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX05469.1; -; Genomic_DNA.
DR EMBL; BC034431; AAH34431.1; ALT_FRAME; mRNA.
DR CCDS; CCDS47059.1; -.
DR RefSeq; NP_689614.2; NM_152401.2.
DR PDB; 3EVI; X-ray; 2.70 A; A/B=88-205.
DR PDBsum; 3EVI; -.
DR AlphaFoldDB; Q8N4E4; -.
DR SMR; Q8N4E4; -.
DR BioGRID; 126343; 8.
DR STRING; 9606.ENSP00000295645; -.
DR iPTMnet; Q8N4E4; -.
DR PhosphoSitePlus; Q8N4E4; -.
DR BioMuta; PDCL2; -.
DR DMDM; 215273865; -.
DR jPOST; Q8N4E4; -.
DR MassIVE; Q8N4E4; -.
DR PaxDb; Q8N4E4; -.
DR PeptideAtlas; Q8N4E4; -.
DR PRIDE; Q8N4E4; -.
DR ProteomicsDB; 71924; -.
DR Antibodypedia; 44095; 80 antibodies from 24 providers.
DR DNASU; 132954; -.
DR Ensembl; ENST00000295645.9; ENSP00000295645.4; ENSG00000163440.12.
DR GeneID; 132954; -.
DR KEGG; hsa:132954; -.
DR MANE-Select; ENST00000295645.9; ENSP00000295645.4; NM_152401.3; NP_689614.2.
DR UCSC; uc003hbb.3; human.
DR CTD; 132954; -.
DR DisGeNET; 132954; -.
DR GeneCards; PDCL2; -.
DR HGNC; HGNC:29524; PDCL2.
DR HPA; ENSG00000163440; Tissue enriched (testis).
DR MIM; 611676; gene.
DR neXtProt; NX_Q8N4E4; -.
DR OpenTargets; ENSG00000163440; -.
DR PharmGKB; PA134987062; -.
DR VEuPathDB; HostDB:ENSG00000163440; -.
DR eggNOG; KOG3170; Eukaryota.
DR GeneTree; ENSGT00940000160654; -.
DR HOGENOM; CLU_072604_0_0_1; -.
DR InParanoid; Q8N4E4; -.
DR OMA; DMRAIEI; -.
DR OrthoDB; 1247977at2759; -.
DR PhylomeDB; Q8N4E4; -.
DR TreeFam; TF315179; -.
DR PathwayCommons; Q8N4E4; -.
DR SignaLink; Q8N4E4; -.
DR BioGRID-ORCS; 132954; 63 hits in 1056 CRISPR screens.
DR EvolutionaryTrace; Q8N4E4; -.
DR GenomeRNAi; 132954; -.
DR Pharos; Q8N4E4; Tbio.
DR PRO; PR:Q8N4E4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N4E4; protein.
DR Bgee; ENSG00000163440; Expressed in right testis and 44 other tissues.
DR Genevisible; Q8N4E4; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02114; Phosducin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..241
FT /note="Phosducin-like protein 2"
FT /id="PRO_0000246157"
FT REGION 89..241
FT /note="Thioredoxin fold"
FT /evidence="ECO:0000250"
FT CONFLICT 62
FT /note="D -> N (in Ref. 3; AAH34431)"
FT /evidence="ECO:0000305"
FT HELIX 97..99
FT /evidence="ECO:0007829|PDB:3EVI"
FT HELIX 100..103
FT /evidence="ECO:0007829|PDB:3EVI"
FT TURN 104..106
FT /evidence="ECO:0007829|PDB:3EVI"
FT STRAND 112..118
FT /evidence="ECO:0007829|PDB:3EVI"
FT HELIX 123..138
FT /evidence="ECO:0007829|PDB:3EVI"
FT STRAND 142..148
FT /evidence="ECO:0007829|PDB:3EVI"
FT HELIX 149..151
FT /evidence="ECO:0007829|PDB:3EVI"
FT HELIX 158..160
FT /evidence="ECO:0007829|PDB:3EVI"
FT STRAND 162..168
FT /evidence="ECO:0007829|PDB:3EVI"
FT STRAND 171..178
FT /evidence="ECO:0007829|PDB:3EVI"
FT TURN 179..183
FT /evidence="ECO:0007829|PDB:3EVI"
FT HELIX 189..197
FT /evidence="ECO:0007829|PDB:3EVI"
FT TURN 198..200
FT /evidence="ECO:0007829|PDB:3EVI"
SQ SEQUENCE 241 AA; 28071 MW; F2F21C7252EE45CB CRC64;
MQDPNEDTEW NDILRDFGIL PPKEESKDEI EEMVLRLQKE AMVKPFEKMT LAQLKEAEDE
FDEEDMQAVE TYRKKRLQEW KALKKKQKFG ELREISGNQY VNEVTNAEED VWVIIHLYRS
SIPMCLLVNQ HLSLLARKFP ETKFVKAIVN SCIQHYHDNC LPTIFVYKNG QIEAKFIGII
ECGGINLKLE ELEWKLAEVG AIQTDLEENP RKDMVDMMVS SIRNTSIHDD SDSSNSDNDT
K
