PDD2L_HUMAN
ID PDD2L_HUMAN Reviewed; 358 AA.
AC Q9BRP1;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Programmed cell death protein 2-like;
GN Name=PDCD2L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17393540; DOI=10.1002/cbf.1410;
RA Chen Q., Yan C., Yan Q., Feng L., Chen J., Qian K.;
RT "The novel MGC13096 protein is correlated with proliferation.";
RL Cell Biochem. Funct. 26:141-145(2008).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND THR-22, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Over-expression suppresses AP1, CREB, NFAT, and NF-kB
CC transcriptional activation, and delays cell cycle progression at S
CC phase. {ECO:0000269|PubMed:17393540}.
CC -!- INTERACTION:
CC Q9BRP1; Q9UKP3: ITGB1BP2; NbExp=2; IntAct=EBI-2372173, EBI-5659717;
CC -!- TISSUE SPECIFICITY: Higher expression in lung, colon, mammary gland,
CC cervix, stomach and small intestine. {ECO:0000269|PubMed:17393540}.
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DR EMBL; AC008747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006146; AAH06146.1; -; mRNA.
DR CCDS; CCDS12438.1; -.
DR RefSeq; NP_115722.1; NM_032346.1.
DR AlphaFoldDB; Q9BRP1; -.
DR BioGRID; 124032; 55.
DR IntAct; Q9BRP1; 26.
DR STRING; 9606.ENSP00000246535; -.
DR GlyGen; Q9BRP1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BRP1; -.
DR PhosphoSitePlus; Q9BRP1; -.
DR BioMuta; PDCD2L; -.
DR DMDM; 74732907; -.
DR EPD; Q9BRP1; -.
DR jPOST; Q9BRP1; -.
DR MassIVE; Q9BRP1; -.
DR MaxQB; Q9BRP1; -.
DR PaxDb; Q9BRP1; -.
DR PeptideAtlas; Q9BRP1; -.
DR PRIDE; Q9BRP1; -.
DR ProteomicsDB; 78794; -.
DR Antibodypedia; 15737; 234 antibodies from 29 providers.
DR DNASU; 84306; -.
DR Ensembl; ENST00000246535.4; ENSP00000246535.1; ENSG00000126249.8.
DR GeneID; 84306; -.
DR KEGG; hsa:84306; -.
DR MANE-Select; ENST00000246535.4; ENSP00000246535.1; NM_032346.2; NP_115722.1.
DR UCSC; uc002nvj.4; human.
DR CTD; 84306; -.
DR GeneCards; PDCD2L; -.
DR HGNC; HGNC:28194; PDCD2L.
DR HPA; ENSG00000126249; Tissue enhanced (skeletal).
DR MIM; 615661; gene.
DR neXtProt; NX_Q9BRP1; -.
DR OpenTargets; ENSG00000126249; -.
DR PharmGKB; PA144596395; -.
DR VEuPathDB; HostDB:ENSG00000126249; -.
DR eggNOG; KOG2061; Eukaryota.
DR GeneTree; ENSGT00940000158339; -.
DR HOGENOM; CLU_034893_1_0_1; -.
DR InParanoid; Q9BRP1; -.
DR OMA; CPQQILR; -.
DR OrthoDB; 1181470at2759; -.
DR PhylomeDB; Q9BRP1; -.
DR TreeFam; TF354282; -.
DR PathwayCommons; Q9BRP1; -.
DR SignaLink; Q9BRP1; -.
DR BioGRID-ORCS; 84306; 53 hits in 1083 CRISPR screens.
DR ChiTaRS; PDCD2L; human.
DR GenomeRNAi; 84306; -.
DR Pharos; Q9BRP1; Tbio.
DR PRO; PR:Q9BRP1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BRP1; protein.
DR Bgee; ENSG00000126249; Expressed in hindlimb stylopod muscle and 172 other tissues.
DR ExpressionAtlas; Q9BRP1; baseline and differential.
DR Genevisible; Q9BRP1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR007320; PDCD2_C.
DR Pfam; PF04194; PDCD2_C; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..358
FT /note="Programmed cell death protein 2-like"
FT /id="PRO_0000272645"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 20
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 22
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 358 AA; 39417 MW; 3946A6E4AD760155 CRC64;
MAAVLKPVLL GLRDAPVHGS PTGPGAWTAS KLGGIPDALP TVAAPRPVCQ RCGQPLALVV
QVYCPLEGSP FHRLLHVFAC ACPGCSTGGA RSWKVFRSQC LQVPEREAQD AQKQGNSLAA
EDWCEGADDW GSDTEEGPSP QFTLDFGNDA SSAKDVDWTA RLQDLRLQDA VLGAAHPVPP
GLPLFLPYYI CVADEDDYRD FVNLDHAHSL LRDYQQREGI AMDQLLSQSL PNDGDEKYEK
TIIKSGDQTF YKFMKRIAAC QEQILRYSWS GEPLFLTCPT SEVTELPACS QCGGQRIFEF
QLMPALVSML KSANLGLSVE FGTILVYTCE KSCWPPNHQT PMEEFCIIQE DPDELLFK
