ID   PDD2L_MOUSE             Reviewed;         364 AA.
AC   Q8C5N5; Q8R185; Q9D1M3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Programmed cell death protein 2-like;
GN   Name=Pdcd2l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Embryo, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Over-expression suppresses AP1, CREB, NFAT, and NF-kB
CC       transcriptional activation, and delays cell cycle progression at S
CC       phase. {ECO:0000250}.
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DR   EMBL; AK003339; BAB22726.1; -; mRNA.
DR   EMBL; AK077948; BAC37080.1; -; mRNA.
DR   EMBL; AK151495; BAE30447.1; -; mRNA.
DR   EMBL; AK154811; BAE32845.1; -; mRNA.
DR   EMBL; BC025090; AAH25090.1; -; mRNA.
DR   EMBL; BC115797; AAI15798.1; -; mRNA.
DR   CCDS; CCDS21137.1; -.
DR   RefSeq; NP_080825.1; NM_026549.3.
DR   AlphaFoldDB; Q8C5N5; -.
DR   BioGRID; 212644; 4.
DR   STRING; 10090.ENSMUSP00000002710; -.
DR   iPTMnet; Q8C5N5; -.
DR   PhosphoSitePlus; Q8C5N5; -.
DR   EPD; Q8C5N5; -.
DR   MaxQB; Q8C5N5; -.
DR   PaxDb; Q8C5N5; -.
DR   PRIDE; Q8C5N5; -.
DR   ProteomicsDB; 287902; -.
DR   DNASU; 68079; -.
DR   Ensembl; ENSMUST00000002710; ENSMUSP00000002710; ENSMUSG00000002635.
DR   GeneID; 68079; -.
DR   KEGG; mmu:68079; -.
DR   UCSC; uc009giw.1; mouse.
DR   CTD; 84306; -.
DR   MGI; MGI:1915329; Pdcd2l.
DR   VEuPathDB; HostDB:ENSMUSG00000002635; -.
DR   eggNOG; KOG2061; Eukaryota.
DR   GeneTree; ENSGT00940000158339; -.
DR   HOGENOM; CLU_034893_1_0_1; -.
DR   InParanoid; Q8C5N5; -.
DR   OMA; CPQQILR; -.
DR   OrthoDB; 1181470at2759; -.
DR   PhylomeDB; Q8C5N5; -.
DR   TreeFam; TF354282; -.
DR   BioGRID-ORCS; 68079; 9 hits in 75 CRISPR screens.
DR   ChiTaRS; Pdcd2l; mouse.
DR   PRO; PR:Q8C5N5; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8C5N5; protein.
DR   Bgee; ENSMUSG00000002635; Expressed in primary oocyte and 260 other tissues.
DR   ExpressionAtlas; Q8C5N5; baseline and differential.
DR   Genevisible; Q8C5N5; MM.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR007320; PDCD2_C.
DR   Pfam; PF04194; PDCD2_C; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell cycle; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRP1"
FT   CHAIN           2..364
FT                   /note="Programmed cell death protein 2-like"
FT                   /id="PRO_0000272646"
FT   REGION          125..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BRP1"
FT   CONFLICT        92
FT                   /note="S -> T (in Ref. 1; BAB22726)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        118
FT                   /note="L -> V (in Ref. 1; BAB22726)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   364 AA;  39955 MW;  5CC9853B7B588EFF CRC64;
     MAAVRKPVLL GLRDTAVKGC PKGPSAWTSS KLGGVPDALP AVTTPGPQCG RCAQPLTLVV
     QVYCPLDGSP FHRLLYVFAC ARPGCGNSQT RSWKVFRSQC LQVPEKETWN AQNQSDSLAA
     ENWCEGSQDW GSDTEETPPP PASDLGSDSN DVRALDWTEK LQALRLQDTA LAVTCPSPSG
     EGLTVPTAVP QFQPYYICVA EEEDYGSVVD LDHAHSLLQE YQRREGVDME QLLSLGSSDG
     DEKYEKTTVS SGDPTFYRFM KRIAACQEQI LRYSWSGEPL FLSCPTFEVS EVPACSGCGG
     QRTFEFQLMP ALVSMLSSAN LGLAVEFGTI LVYTCKQSCW PPNQQMPMEE FCVLQEDPDE
     FLFK