ID   PDF2_CAEEL              Reviewed;          89 AA.
AC   G5EGC3;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Pigment dispersing factor homolog pdf-2 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=pdf-2 {ECO:0000312|WormBase:F48B9.4};
GN   Synonyms=nlp-37 {ECO:0000312|WormBase:F48B9.4},
GN   pdf2 {ECO:0000312|EMBL:ABO42260.1};
GN   ORFNames=F48B9.4 {ECO:0000312|WormBase:F48B9.4};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|EMBL:ABO42260.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=19686386; DOI=10.1111/j.1471-4159.2009.06323.x;
RA   Janssen T., Husson S.J., Meelkop E., Temmerman L., Lindemans M.,
RA   Verstraelen K., Rademakers S., Mertens I., Nitabach M., Jansen G.,
RA   Schoofs L.;
RT   "Discovery and characterization of a conserved pigment dispersing factor-
RT   like neuropeptide pathway in Caenorhabditis elegans.";
RL   J. Neurochem. 111:228-241(2009).
RN   [2] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=18390545; DOI=10.1074/jbc.m709060200;
RA   Janssen T., Husson S.J., Lindemans M., Mertens I., Rademakers S.,
RA   Donck K.V., Geysen J., Jansen G., Schoofs L.;
RT   "Functional characterization of three G protein-coupled receptors for
RT   pigment dispersing factors in Caenorhabditis elegans.";
RL   J. Biol. Chem. 283:15241-15249(2008).
RN   [4] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=22579613; DOI=10.1016/j.mce.2012.05.001;
RA   Meelkop E., Temmerman L., Janssen T., Suetens N., Beets I., Van Rompay L.,
RA   Shanmugam N., Husson S.J., Schoofs L.;
RT   "PDF receptor signaling in Caenorhabditis elegans modulates locomotion and
RT   egg-laying.";
RL   Mol. Cell. Endocrinol. 361:232-240(2012).
RN   [5] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=26113231; DOI=10.1111/gbb.12231;
RA   Herrero A., Romanowski A., Meelkop E., Caldart C.S., Schoofs L.,
RA   Golombek D.A.;
RT   "Pigment-dispersing factor signaling in the circadian system of
RT   Caenorhabditis elegans.";
RL   Genes Brain Behav. 14:493-501(2015).
CC   -!- FUNCTION: Probable ligand of isoforms a and b of the calcitonin
CC       receptor-like protein, pdfr-1, a G-protein coupled receptor
CC       (PubMed:18390545). May not signal through isoform c of pdfr-1
CC       (PubMed:18390545). Involved in locomotion; may play a role in circadian
CC       rhythms of locomotor activity (PubMed:18390545, PubMed:22579613,
CC       PubMed:26113231). Modulator of egg-laying (PubMed:22579613).
CC       {ECO:0000269|PubMed:18390545, ECO:0000269|PubMed:22579613,
CC       ECO:0000269|PubMed:26113231}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the interneurons BDUL/R, AVG, AIML/R,
CC       RIS, AVD and PVT, the chemosensory neuron pairs PHA and PHB, the motor
CC       neurons RID and RIML/R, the sensory neurons AQR and PQR, and in the
CC       PVPL/R interneurons (PubMed:19686386). Also expressed in rectal gland
CC       cells rectD and rectVL/R, the intestino-rectal valve cells virL/R and
CC       three posterior arcade cells in the head (PubMed:19686386).
CC       {ECO:0000269|PubMed:19686386}.
CC   -!- DISRUPTION PHENOTYPE: Delay in the timing of the reproductive peak of
CC       egg-laying. {ECO:0000269|PubMed:22579613}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EF141321; ABO42260.1; -; mRNA.
DR   EMBL; BX284606; CCD68823.1; -; Genomic_DNA.
DR   PIR; T16394; T16394.
DR   RefSeq; NP_508397.2; NM_075996.2.
DR   AlphaFoldDB; G5EGC3; -.
DR   STRING; 6239.F48B9.4; -.
DR   EPD; G5EGC3; -.
DR   PaxDb; G5EGC3; -.
DR   EnsemblMetazoa; F48B9.4.1; F48B9.4.1; WBGene00018590.
DR   GeneID; 185966; -.
DR   KEGG; cel:CELE_F48B9.4; -.
DR   CTD; 185966; -.
DR   WormBase; F48B9.4; CE30276; WBGene00018590; pdf-2.
DR   eggNOG; ENOG502SXAU; Eukaryota.
DR   HOGENOM; CLU_2471188_0_0_1; -.
DR   InParanoid; G5EGC3; -.
DR   OMA; PAYAPHV; -.
DR   OrthoDB; 1597851at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00018590; Expressed in larva and 3 other tissues.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IMP:UniProtKB.
DR   GO; GO:0040011; P:locomotion; IMP:UniProtKB.
DR   GO; GO:0045475; P:locomotor rhythm; IMP:UniProtKB.
DR   GO; GO:0007567; P:parturition; IMP:UniProtKB.
PE   2: Evidence at transcript level;
KW   Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..89
FT                   /note="Pigment dispersing factor homolog pdf-2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5015092027"
SQ   SEQUENCE   89 AA;  9917 MW;  E6645470792F1A71 CRC64;
     MSSRISVSLL LLAVVATMFF TANVVDATPR SQGNMMRYGN SLPAYAPHVL YRFYNSRQFA
     PINKRNNAEV VNHILKNFGA LDRLGDVGK