ID   PDGFB_PIG               Reviewed;          15 AA.
AC   P20034;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 63.
DE   RecName: Full=Platelet-derived growth factor subunit B;
DE            Short=PDGF subunit B;
DE   AltName: Full=PDGF-2;
DE   AltName: Full=Platelet-derived growth factor B chain;
DE   AltName: Full=Platelet-derived growth factor beta polypeptide;
DE   Flags: Fragment;
GN   Name=PDGFB;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6526008; DOI=10.1002/j.1460-2075.1984.tb02241.x;
RA   Stroobant P., Waterfield M.D.;
RT   "Purification and properties of porcine platelet-derived growth factor.";
RL   EMBO J. 3:2963-2967(1984).
CC   -!- FUNCTION: Growth factor that plays an essential role in the regulation
CC       of embryonic development, cell proliferation, cell migration, survival
CC       and chemotaxis. Potent mitogen for cells of mesenchymal origin.
CC       Required for normal proliferation and recruitment of pericytes and
CC       vascular smooth muscle cells in the central nervous system, skin, lung,
CC       heart and placenta. Required for normal blood vessel development, and
CC       for normal development of kidney glomeruli. Plays an important role in
CC       wound healing. Signaling is modulated by the formation of heterodimers
CC       with PDGFA (By similarity). {ECO:0000250|UniProtKB:P01127,
CC       ECO:0000250|UniProtKB:P31240}.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked. Antiparallel
CC       heterodimer with PDGFA; disulfide-linked. The PDGFB homodimer interacts
CC       with PDGFRA and PDGFRB homodimers, and with heterodimers formed by
CC       PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB
CC       interacts with PDGFRB homodimers, and with heterodimers formed by
CC       PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity). Interacts with
CC       LRP1 (By similarity). Interacts with SORL1 (via the N-terminal
CC       ectodomain) (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:P01127}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon
CC       wounding. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000305}.
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DR   PIR; A22789; A22789.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Developmental protein; Direct protein sequencing; Disulfide bond;
KW   Growth factor; Mitogen; Proto-oncogene; Reference proteome; Secreted.
FT   CHAIN           1..>15
FT                   /note="Platelet-derived growth factor subunit B"
FT                   /id="PRO_0000162359"
FT   NON_TER         15
SQ   SEQUENCE   15 AA;  1411 MW;  DCC39014450251C2 CRC64;
     SLGSPAVAEP AVIAE