ID   PDH1_CALSI              Reviewed;          78 AA.
AC   Q23755;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Pigment-dispersing hormone 1 peptides;
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide 1;
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone 1;
DE              Short=PDH 1;
DE   Flags: Precursor;
GN   Name=PDH1;
OS   Callinectes sapidus (Blue crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Portunidae; Callinectes.
OX   NCBI_TaxID=6763;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=7999056; DOI=10.1006/bbrc.1994.2680;
RA   Klein J.M., Mohrherr C.J., Sleutels F., Riehm J.P., Rao K.R.;
RT   "Molecular cloning of two pigment-dispersing hormone (PDH) precursors in
RT   the blue crab Callinectes sapidus reveals a novel member of the PDH
RT   neuropeptide family.";
RL   Biochem. Biophys. Res. Commun. 205:410-416(1994).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Eyestalk sinus gland.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; L36716; AAA67052.1; -; mRNA.
DR   PIR; JC2428; JC2428.
DR   AlphaFoldDB; Q23755; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..55
FT                   /note="PDH precursor-related peptide 1"
FT                   /id="PRO_0000023427"
FT   PEPTIDE         58..75
FT                   /note="Pigment-dispersing hormone 1"
FT                   /id="PRO_0000023428"
FT   MOD_RES         75
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8539 MW;  926AACDBE133DB50 CRC64;
     MRSSVIVAVL VVVALAALLT QGQELKYQER EMVAELAQQI YRVAQAPWAA AVGPHKRNSE
     LINSILGLPK VMNDAGRR