ASPX_MOUSE
ID ASPX_MOUSE Reviewed; 261 AA.
AC P50289; B2RT20; Q9DAM6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Acrosomal protein SP-10;
DE AltName: Full=Acrosomal vesicle protein 1;
DE AltName: Full=MSA-63;
DE Flags: Precursor;
GN Name=Acrv1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=8547483; DOI=10.1095/biolreprod53.4.873;
RA Reddi P.P., Naaby-Hansen S., Aguolnik I., Tsai J.-Y., Silver L.M.,
RA Flickinger C.J., Herr J.C.;
RT "Complementary deoxyribonucleic acid cloning and characterization of mSP-
RT 10: the mouse homologue of human acrosomal protein SP-10.";
RL Biol. Reprod. 53:873-881(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1; TISSUE=Testis;
RA Reddi P.P., Tsai J.-Y., Bollag R., Silver L.M., Herr J.C.;
RT "Molecular cloning and genomic localisation of mSP-10, a murine homologue
RT for human acrosomal protein, SP-10.";
RL Am. J. Reprod. Immunol. 31:225-225(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 56-62; 201-211 AND
RP 247-250.
RC STRAIN=CD-1; TISSUE=Testis;
RX PubMed=1591350; DOI=10.1095/biolreprod46.5.937;
RA Liu M.-S., Aebersold R., Fann C.-H., Lee C.-Y.G.;
RT "Molecular and developmental studies of a sperm acrosome antigen recognized
RT by HS-63 monoclonal antibody.";
RL Biol. Reprod. 46:937-948(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- PTM: The N-terminus is blocked.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U31992; AAA91652.1; -; mRNA.
DR EMBL; L31920; AAA40122.1; -; mRNA.
DR EMBL; AK005705; BAB24197.1; -; mRNA.
DR EMBL; AC155921; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466522; EDL25409.1; -; Genomic_DNA.
DR EMBL; BC139101; AAI39102.1; -; mRNA.
DR EMBL; BC139103; AAI39104.1; -; mRNA.
DR CCDS; CCDS22971.1; -.
DR RefSeq; NP_031417.2; NM_007391.2.
DR AlphaFoldDB; P50289; -.
DR SMR; P50289; -.
DR STRING; 10090.ENSMUSP00000034620; -.
DR PaxDb; P50289; -.
DR PeptideAtlas; P50289; -.
DR PRIDE; P50289; -.
DR ProteomicsDB; 277049; -.
DR Antibodypedia; 32960; 219 antibodies from 26 providers.
DR DNASU; 11451; -.
DR Ensembl; ENSMUST00000034620; ENSMUSP00000034620; ENSMUSG00000032110.
DR GeneID; 11451; -.
DR KEGG; mmu:11451; -.
DR UCSC; uc009ott.1; mouse.
DR CTD; 56; -.
DR MGI; MGI:104590; Acrv1.
DR VEuPathDB; HostDB:ENSMUSG00000032110; -.
DR eggNOG; ENOG502QRB1; Eukaryota.
DR GeneTree; ENSGT00940000162351; -.
DR HOGENOM; CLU_070242_0_0_1; -.
DR InParanoid; P50289; -.
DR OMA; ENSQQCM; -.
DR OrthoDB; 1435784at2759; -.
DR PhylomeDB; P50289; -.
DR TreeFam; TF337781; -.
DR BioGRID-ORCS; 11451; 0 hits in 59 CRISPR screens.
DR PRO; PR:P50289; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P50289; protein.
DR Bgee; ENSMUSG00000032110; Expressed in spermatid and 22 other tissues.
DR Genevisible; P50289; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR CDD; cd00117; LU; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Repeat; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..261
FT /note="Acrosomal protein SP-10"
FT /id="PRO_0000020761"
FT REGION 50..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 184
FT /note="I -> L (in Ref. 1; AAA91652 and 3; AAA40122)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 27948 MW; B4425A32D68BA23A CRC64;
MKELILLGLY LLGSAQGAPP GQPEELLDSV DQQASVQQLS SEYLSLANPS DAEALYETPL
DEKTLSGHSS SEQESSEHAV AEHSAGEHSS GEQSSEHMSG DHMSGEHLSE HTSEEHSSGE
HTSTEHTSGE QPATEQSSSD QPSEASSGEV SGDEAGEQVS SETNDKENDA MSTPLPSTSA
AITINCHTCA YMNDDAKCLR GEGVCTTQNS QQCMLKKIFE GGKLQFMVQG CENMCPSMNL
FSHGTRMQIM CCRNEPLCNK V
