PDH1_SCHPO
ID PDH1_SCHPO Reviewed; 226 AA.
AC O42826;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Protein pdh1;
DE Flags: Precursor;
GN Name=pdh1; ORFNames=SPCC1235.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=JY336;
RX PubMed=9501995; DOI=10.1093/dnares/4.6.393;
RA Iha H., Takimoto M., Danjoh I., Fujiyama A.;
RT "Identification and characterization of a novel trans-membrane protein
RT gene, pdh1, from Schizosaccharomyces pombe.";
RL DNA Res. 4:393-396(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; D88384; BAA24946.1; -; Genomic_DNA.
DR EMBL; CU329672; CAA21112.1; -; Genomic_DNA.
DR PIR; JC5966; JC5966.
DR RefSeq; NP_587734.1; NM_001022729.2.
DR AlphaFoldDB; O42826; -.
DR BioGRID; 275616; 16.
DR STRING; 4896.SPCC1235.08c.1; -.
DR PaxDb; O42826; -.
DR EnsemblFungi; SPCC1235.08c.1; SPCC1235.08c.1:pep; SPCC1235.08c.
DR GeneID; 2539043; -.
DR KEGG; spo:SPCC1235.08c; -.
DR PomBase; SPCC1235.08c; pdh1.
DR VEuPathDB; FungiDB:SPCC1235.08c; -.
DR eggNOG; KOG2890; Eukaryota.
DR HOGENOM; CLU_1225410_0_0_1; -.
DR InParanoid; O42826; -.
DR OMA; FIAYKIT; -.
DR PhylomeDB; O42826; -.
DR PRO; PR:O42826; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0030137; C:COPI-coated vesicle; ISO:PomBase.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; ISO:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISS:PomBase.
DR Gene3D; 1.20.1540.10; -; 1.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR013861; TMEM115/Pdh1/Rbl19.
DR PANTHER; PTHR13377; PTHR13377; 1.
DR Pfam; PF08551; DUF1751; 1.
DR SUPFAM; SSF144091; SSF144091; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..226
FT /note="Protein pdh1"
FT /id="PRO_0000022033"
FT TOPO_DOM 27..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 226 AA; 26021 MW; 3C71DB50ECB317B1 CRC64;
MNHFSKFSVT KRLLILEVLF SAISFGISIY IKVFGRSSIV TFFLLCFHLV PNALFLFPWT
IITTSFVDAN VFTLLSSILI LSVYGVEIER SWGHKEYLLF CQFLTVIPNI AVLIPCFIAY
KITDSHYLLV AIIQSTTAIQ AGILTAWYQL YSCKKEESSN KFLCPLSKYL IYLFLSIHLF
YVFQSFPWTY FCLAVSGTCI SELYVLFVHP VVQELFHLES HTQLPI
