ID   PDH2_CALSI              Reviewed;          78 AA.
AC   Q23756;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Pigment-dispersing hormone 2 peptides;
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide 2;
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone 2;
DE              Short=PDH 2;
DE   Flags: Precursor;
GN   Name=PDH2;
OS   Callinectes sapidus (Blue crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Portunidae; Callinectes.
OX   NCBI_TaxID=6763;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=7999056; DOI=10.1006/bbrc.1994.2680;
RA   Klein J.M., Mohrherr C.J., Sleutels F., Riehm J.P., Rao K.R.;
RT   "Molecular cloning of two pigment-dispersing hormone (PDH) precursors in
RT   the blue crab Callinectes sapidus reveals a novel member of the PDH
RT   neuropeptide family.";
RL   Biochem. Biophys. Res. Commun. 205:410-416(1994).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Eyestalk sinus gland.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; L36717; AAA67053.1; -; mRNA.
DR   PIR; JC2427; JC2427.
DR   AlphaFoldDB; Q23756; -.
DR   SMR; Q23756; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         22..55
FT                   /note="PDH precursor-related peptide 2"
FT                   /id="PRO_0000023429"
FT   PEPTIDE         58..75
FT                   /note="Pigment-dispersing hormone 2"
FT                   /id="PRO_0000023430"
FT   MOD_RES         75
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8344 MW;  4450E0A2745A9CCB CRC64;
     MRSGVFVAVL VVVVFALLTQ GQELHVPERE AVANLAARIL KIVHAPHDAA AGVPHKRNSE
     LINSLLGISA LMNEAGRR