ID   PDH2_PENVA              Reviewed;          80 AA.
AC   P91964;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Pigment-dispersing hormone type 2;
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide;
DE              Short=PPRD;
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone;
DE              Short=PDH;
DE   Flags: Precursor;
GN   Name=PDH2;
OS   Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=8630031; DOI=10.1006/bbrc.1996.0666;
RA   Desmoucelles-Carette C., Sellos D., Van Wormhoudt A.;
RT   "Molecular cloning of the precursors of pigment-dispersing hormone in
RT   Crustaceans.";
RL   Biochem. Biophys. Res. Commun. 221:739-743(1996).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Eyestalk.
CC   -!- MISCELLANEOUS: The function of PDH precursor-related peptide is
CC       unknown. The sequence is not well-conserved among different species and
CC       that might be an indication that it is inactive.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; Y11722; CAA72408.1; -; mRNA.
DR   PIR; JC4757; JC4757.
DR   AlphaFoldDB; P91964; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..57
FT                   /note="PDH precursor-related peptide"
FT                   /id="PRO_0000043333"
FT   PEPTIDE         60..77
FT                   /note="Pigment-dispersing hormone"
FT                   /id="PRO_0000043334"
FT   MOD_RES         77
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   80 AA;  8670 MW;  5D799F3606C6A287 CRC64;
     MARCFVVLAF LALAAMSLQV ATAQDDLKYF EREVVAELAA QILRVAQGPS AFVAGPHKRN
     SELINSLLGI PKVMNDAGRR