ID   PDHA_FAXLI              Reviewed;          76 AA.
AC   P37085;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Pigment-dispersing hormone A peptides;
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide;
DE              Short=PRPP;
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone A;
DE              Short=PDH A;
DE     AltName: Full=Light-adapting distal retinal pigment hormone A;
DE              Short=DRPH A;
DE   Flags: Precursor;
OS   Faxonius limosus (Spinycheek crayfish) (Orconectes limosus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Faxonius.
OX   NCBI_TaxID=28379;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Eyestalk;
RX   PubMed=8477858; DOI=10.1016/0014-5793(93)80119-f;
RA   de Kleijn D.P., Linck B., Klein J.M., Weidemann W.M., Keller R.,
RA   van Herp F.;
RT   "Structure and localization of mRNA encoding a pigment dispersing hormone
RT   (PDH) in the eyestalk of the crayfish Orconectes limosus.";
RL   FEBS Lett. 321:251-255(1993).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Optical ganglia of the eyestalk.
CC       {ECO:0000269|PubMed:8477858}.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; S59496; AAB26385.1; -; mRNA.
DR   PIR; S32498; S32498.
DR   AlphaFoldDB; P37085; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         21..53
FT                   /note="PDH precursor-related peptide"
FT                   /id="PRO_0000023433"
FT   PEPTIDE         56..73
FT                   /note="Pigment-dispersing hormone A"
FT                   /id="PRO_0000023434"
FT   MOD_RES         73
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   76 AA;  8281 MW;  F519F39CB833572D CRC64;
     MRSAMVVLVL VAMVAVFTRA QELKYPEREV VAELAAQIYG WPGSLGTMAG GPHKRNSELI
     NSILGLPKVM NEAGRR