ID   PDHC_FAXLI              Reviewed;          18 AA.
AC   P83587;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Pigment-dispersing hormone C;
DE            Short=PDH C;
DE   AltName: Full=Light-adapting distal retinal pigment hormone C;
DE            Short=DRPH C;
OS   Faxonius limosus (Spinycheek crayfish) (Orconectes limosus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Faxonius.
OX   NCBI_TaxID=28379 {ECO:0000305};
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND AMIDATION AT VAL-18.
RC   TISSUE=Eyestalk;
RX   PubMed=14981133; DOI=10.1074/mcp.m300076-mcp200;
RA   Bulau P., Meisen I., Schmitz T., Keller R., Peter-Katalinic J.;
RT   "Identification of neuropeptides from the sinus gland of the crayfish
RT   Orconectes limosus using nanoscale on-line liquid chromatography tandem
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 3:558-564(2004).
CC   -!- FUNCTION: Causes the migration of the distal retinal pigment into the
CC       proximal end of the pigment chromatophore cells and thus decreases the
CC       amount of light entering the retinulas. May also function as a
CC       neurotransmitter and/or neuromodulator (By similarity).
CC       {ECO:0000250|UniProtKB:P37085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14981133,
CC       ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Eyestalk sinus gland.
CC       {ECO:0000269|PubMed:14981133}.
CC   -!- MASS SPECTROMETRY: Mass=1855.92; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:14981133};
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   AlphaFoldDB; P83587; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Neurotransmitter; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Pigment-dispersing hormone C"
FT                   /id="PRO_0000044233"
FT   MOD_RES         18
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000269|PubMed:14981133"
SQ   SEQUENCE   18 AA;  1858 MW;  F9C472ABCE9DC45C CRC64;
     NSELINAILG SPTLMGEV