ASPX_PAPHA
ID ASPX_PAPHA Reviewed; 285 AA.
AC Q06990;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Acrosomal protein SP-10;
DE AltName: Full=Acrosomal vesicle protein 1;
DE Flags: Precursor;
GN Name=ACRV1;
OS Papio hamadryas (Hamadryas baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9557;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=8442953; DOI=10.1002/mrd.1080340205;
RA Freemerman A.J., Wright R.M., Flickinger C.J., Herr J.C.;
RT "Cloning and sequencing of baboon and cynomolgus monkey intra-acrosomal
RT protein SP-10: homology with human SP-10 and a mouse sperm antigen (MSA-
RT 63).";
RL Mol. Reprod. Dev. 34:140-148(1993).
RN [2]
RP CHARACTERIZATION.
RX PubMed=8167233; DOI=10.1095/biolreprod50.3.615;
RA Freemerman A.J., Wright R.M., Flickinger C.J., Herr J.C.;
RT "Tissue specificity of the acrosomal protein SP-10: a contraceptive vaccine
RT candidate molecule.";
RL Biol. Reprod. 50:615-621(1994).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome.
CC Note=Nascent acrosomal vesicle of Golgi phase spermatids.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q06990-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q06990-2; Sequence=VSP_004129;
CC -!- TISSUE SPECIFICITY: Testis.
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DR EMBL; S56458; AAB25692.1; -; mRNA.
DR EMBL; S56458; AAB25693.1; -; mRNA.
DR AlphaFoldDB; Q06990; -.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR CDD; cd00117; LU; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasmic vesicle; Glycoprotein; Repeat; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..285
FT /note="Acrosomal protein SP-10"
FT /id="PRO_0000020762"
FT REPEAT 66..70
FT /note="1-1"
FT REPEAT 71..75
FT /note="1-2"
FT REPEAT 85..89
FT /note="2-1"
FT REPEAT 91..95
FT /note="1-3"
FT REPEAT 110..114
FT /note="3-1"
FT REPEAT 115..119
FT /note="3-2"
FT REPEAT 120..124
FT /note="2-2"
FT REPEAT 125..129
FT /note="3-3"
FT REPEAT 130..134
FT /note="2-3"
FT REPEAT 135..139
FT /note="3-4"
FT REPEAT 145..149
FT /note="2-4"
FT REPEAT 150..154
FT /note="3-5"
FT REPEAT 155..159
FT /note="2-5"
FT REPEAT 160..164
FT /note="3-6"
FT REPEAT 165..169
FT /note="3-7"
FT REPEAT 170..174
FT /note="2-6"
FT REPEAT 175..179
FT /note="3-8"
FT REPEAT 180..184
FT /note="2-7"
FT REPEAT 190..194
FT /note="3-9"
FT REGION 64..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..95
FT /note="3 X 5 AA repeats of S-E-H-[GA]-A"
FT REGION 85..184
FT /note="7 X 5 AA repeats of S-G-E-H-[AL]"
FT REGION 110..194
FT /note="9 X 5 AA repeats of [SV]-G-E-Q-[PSA]"
FT COMPBIAS 70..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 278
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 172..205
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_004129"
SQ SEQUENCE 285 AA; 30129 MW; 524E115F72AA0D0E CRC64;
MNMFLLLMSL YLLGSARGTS GQSDESSGSI DHQTSVQQLS GEFFSLENPS DAEALYETAS
GLNTLSEHGS SEHGSREHTV AEHTPGEHAE SEHASGEPAA TGHAEGEHTV GEQPSGEQPS
GEHLSGEQSL GEHASGEQPS DEQLSGEHAS GEQPSGEHAS GEQPSGEQPS GEHASGEQSL
GEHALSEKPS GEQPSGAPIS SISTGTILNC YTCAYMNDQG RCLRGEGTCI TQNSQQCMLK
KIFEGGKLQF MVQGCENMCP SMNLFSHGTR MQIICCRNQS FCNKI
