PDHR_SALTI
ID PDHR_SALTI Reviewed; 254 AA.
AC P0A2S3; Q9L4H9;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Pyruvate dehydrogenase complex repressor;
GN Name=pdhR; OrderedLocusNames=STY0174, t0157;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC complex genes aceEF and lpd. {ECO:0000250}.
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DR EMBL; AL513382; CAD01310.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO67889.1; -; Genomic_DNA.
DR RefSeq; NP_454765.1; NC_003198.1.
DR RefSeq; WP_000331771.1; NZ_WSUR01000009.1.
DR AlphaFoldDB; P0A2S3; -.
DR SMR; P0A2S3; -.
DR STRING; 220341.16501438; -.
DR EnsemblBacteria; AAO67889; AAO67889; t0157.
DR KEGG; stt:t0157; -.
DR KEGG; sty:STY0174; -.
DR PATRIC; fig|220341.7.peg.175; -.
DR eggNOG; COG2186; Bacteria.
DR HOGENOM; CLU_017584_9_5_6; -.
DR OMA; EWPVGSR; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.20.120.530; -; 1.
DR InterPro; IPR011711; GntR_C.
DR InterPro; IPR008920; TF_FadR/GntR_C.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF07729; FCD; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00895; FCD; 1.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF48008; SSF48008; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..254
FT /note="Pyruvate dehydrogenase complex repressor"
FT /id="PRO_0000050665"
FT DOMAIN 9..77
FT /note="HTH gntR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT DNA_BIND 37..56
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ SEQUENCE 254 AA; 29412 MW; 990A66833052EAB3 CRC64;
MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS LREAIQRLEA
KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQFDL LETRHALEGI AAYYAALRST
DEDKDRIREL HHAIELAQES GDLDAESEAV LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN
VRQNFELLYA RREMLPLVST HRTRIFEAIM AGKPEEAREA SHRHLAFIEE IMLDRSREES
RRERALRRLE QRKN
