ID   PDHR_SALTS              Reviewed;         254 AA.
AC   E1W823; P0A2S2; Q9L4H9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Pyruvate dehydrogenase complex repressor;
GN   Name=pdhR; OrderedLocusNames=SL1344_0151;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SL1344;
RA   Cano D., Casadesus J., Garcia-del Portillo F.;
RT   "Characterization of a Salmonella-specific region located between ampE and
RT   aroP genes.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC       complex genes aceEF and lpd. {ECO:0000250}.
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DR   EMBL; AJ242516; CAB89840.1; -; Genomic_DNA.
DR   EMBL; FQ312003; CBW16254.1; -; Genomic_DNA.
DR   RefSeq; WP_000331771.1; NZ_QASL01000007.1.
DR   AlphaFoldDB; E1W823; -.
DR   SMR; E1W823; -.
DR   EnsemblBacteria; CBW16254; CBW16254; SL1344_0151.
DR   KEGG; sey:SL1344_0151; -.
DR   PATRIC; fig|216597.6.peg.168; -.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OMA; EWPVGSR; -.
DR   BioCyc; SENT216597:SL1344_RS00770-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Pyruvate dehydrogenase complex repressor"
FT                   /id="PRO_0000405421"
FT   DOMAIN          9..77
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        37..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   CONFLICT        135
FT                   /note="E -> K (in Ref. 1; CAB89840)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   254 AA;  29412 MW;  990A66833052EAB3 CRC64;
     MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS LREAIQRLEA
     KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQFDL LETRHALEGI AAYYAALRST
     DEDKDRIREL HHAIELAQES GDLDAESEAV LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN
     VRQNFELLYA RREMLPLVST HRTRIFEAIM AGKPEEAREA SHRHLAFIEE IMLDRSREES
     RRERALRRLE QRKN