ID   PDHR_SALTY              Reviewed;         254 AA.
AC   P0CL10; P0A2S2; Q9L4H9;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Pyruvate dehydrogenase complex repressor;
GN   Name=pdhR; OrderedLocusNames=STM0151;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Transcriptional repressor for the pyruvate dehydrogenase
CC       complex genes aceEF and lpd. {ECO:0000250}.
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DR   EMBL; AE006468; AAL19115.1; -; Genomic_DNA.
DR   RefSeq; NP_459156.1; NC_003197.2.
DR   RefSeq; WP_000331771.1; NC_003197.2.
DR   AlphaFoldDB; P0CL10; -.
DR   SMR; P0CL10; -.
DR   STRING; 99287.STM0151; -.
DR   PaxDb; P0CL10; -.
DR   EnsemblBacteria; AAL19115; AAL19115; STM0151.
DR   GeneID; 1251669; -.
DR   KEGG; stm:STM0151; -.
DR   PATRIC; fig|99287.12.peg.161; -.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OMA; EWPVGSR; -.
DR   PhylomeDB; P0CL10; -.
DR   BioCyc; SENT99287:STM0151-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Pyruvate dehydrogenase complex repressor"
FT                   /id="PRO_0000050666"
FT   DOMAIN          9..77
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        37..56
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   254 AA;  29412 MW;  990A66833052EAB3 CRC64;
     MAYSKIRQPK LSDVIEQQLE FLILEGTLRP GEKLPPEREL AKQFDVSRPS LREAIQRLEA
     KGLLLRRQGG GTFVQSSLWQ SFSDPLVELL SDHPESQFDL LETRHALEGI AAYYAALRST
     DEDKDRIREL HHAIELAQES GDLDAESEAV LQYQIAVTEA AHNVVLLHLL RCMEPMLAQN
     VRQNFELLYA RREMLPLVST HRTRIFEAIM AGKPEEAREA SHRHLAFIEE IMLDRSREES
     RRERALRRLE QRKN