ID   ASPX_VULVU              Reviewed;         349 AA.
AC   P53353;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Sperm acrosomal protein FSA-ACR.1;
DE   Flags: Precursor; Fragment;
OS   Vulpes vulpes (Red fox).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes.
OX   NCBI_TaxID=9627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
RC   TISSUE=Testis;
RX   PubMed=7766418; DOI=10.1002/mrd.1080400214;
RA   Beaton S., ten Have J., Cleary A., Bradley M.P.;
RT   "Cloning and partial characterization of the cDNA encoding the fox sperm
RT   protein FSA-Acr.1 with similarities to the SP-10 antigen.";
RL   Mol. Reprod. Dev. 40:242-252(1995).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome.
CC       Note=Intracellular acrosomal compartment of sperm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Experimental confirmation may be lacking for some isoforms.;
CC       Name=1; Synonyms=FSA-Acr.1;
CC         IsoId=P53353-1; Sequence=Displayed;
CC       Name=2; Synonyms=FSA-Acr.2;
CC         IsoId=P53353-2; Sequence=VSP_004130, VSP_004131;
CC       Name=3; Synonyms=FSA-Acr.3;
CC         IsoId=P53353-3; Sequence=VSP_004132;
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: To acrosomal proteins SP-10. {ECO:0000305}.
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DR   EMBL; U06077; AAC48463.1; -; mRNA.
DR   AlphaFoldDB; P53353; -.
DR   STRING; 9627.ENSVVUP00000027517; -.
DR   Proteomes; UP000286640; Unplaced.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   CDD; cd00117; LU; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasmic vesicle; Glycoprotein;
KW   Reference proteome; Repeat; Signal.
FT   SIGNAL          <1..8
FT                   /evidence="ECO:0000255"
FT   CHAIN           9..349
FT                   /note="Sperm acrosomal protein FSA-ACR.1"
FT                   /id="PRO_0000020763"
FT   REGION          1..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        342
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         <1..7
FT                   /note="MKEVYLV -> MSLYLI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7766418"
FT                   /id="VSP_004130"
FT   VAR_SEQ         140
FT                   /note="G -> GEQPSGEKSSG (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:7766418"
FT                   /id="VSP_004131"
FT   VAR_SEQ         140
FT                   /note="G -> GEQPSGEKSLGEQPSGEKSSG (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:7766418"
FT                   /id="VSP_004132"
FT   NON_TER         1
SQ   SEQUENCE   349 AA;  36486 MW;  10E762D86805BD83 CRC64;
     MKEVYLVGYA RGASGQSDEP PGSMDHQASV QRLSGEYFSL GNPSDGEALY ETAAGENTLS
     EHTSGEHTSV EHASAEHSST EHTSGEHASG EHTSGERATG EHTSSEHATS EHTSGEQPSG
     EQPSGEKSSG EQPSGEKSSG EQPSGEKSLG EQPSGEQSSG EKSSAEQTSG EQAVAEKPSG
     EHAVAEKPSG EQAVAERPSG EQAVAEKPLG EQAVAERPSG EQASIEKASS EQASAEQASA
     EQASSEQASG EKPLGEQPSG IPPSSTFSGP ILNCHTCSYM NDQGKCLRGE GVCSTQNSQQ
     CMLKKIFEGG KLQFMVQGCE NMCPSMNLFS HGTRMQIICC RNQSFCNKI