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PDH_ARMVU
ID   PDH_ARMVU               Reviewed;          82 AA.
AC   D2Z1D6;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Pigment-dispersing hormone peptides {ECO:0000250|UniProtKB:P08871};
DE            Short=AvPDH {ECO:0000303|PubMed:20637211};
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide {ECO:0000303|PubMed:20637211};
DE              Short=PPRP {ECO:0000303|PubMed:20637211};
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone {ECO:0000303|PubMed:20637211};
DE              Short=PDH {ECO:0000303|PubMed:20637211};
DE   Flags: Precursor;
GN   Name=PDH {ECO:0000312|EMBL:BAI67599.1};
OS   Armadillidium vulgare (Pillbug) (Pill woodlouse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Peracarida; Isopoda; Oniscidea; Crinocheta;
OC   Armadillidiidae; Armadillidium.
OX   NCBI_TaxID=13347;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAI67599.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Head {ECO:0000312|EMBL:BAI67599.1};
RX   PubMed=20637211; DOI=10.1016/j.jinsphys.2010.07.003;
RA   Fouda M.M.A., Hiragaki S., Tufail M., Shao Q.-M., Takeda M.;
RT   "Precursor structure, distribution and possible functions of pigment-
RT   dispersing hormone (PDH) in the terrestrial isopod Armadillidium vulgare
RT   (Latreille).";
RL   J. Insect Physiol. 56:1728-1737(2010).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator (By similarity). {ECO:0000250|UniProtKB:P08871}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P08871}.
CC   -!- TISSUE SPECIFICITY: Expressed strongly in the head and weakly in the
CC       ventral nerve cord. Not detected in the midgut cecum or hindgut. In the
CC       cephalic neural complex, specifically localized to cells within the
CC       optic lobe, anteromedian protocerebrum, accessory lobe, tritocerebrum,
CC       and subesophageal ganglion. {ECO:0000269|PubMed:20637211}.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000255}.
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DR   EMBL; AB543253; BAI67599.1; -; mRNA.
DR   AlphaFoldDB; D2Z1D6; -.
DR   SMR; D2Z1D6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         27..60
FT                   /note="PDH precursor-related peptide"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000423517"
FT   PEPTIDE         63..80
FT                   /note="Pigment-dispersing hormone"
FT                   /evidence="ECO:0000250|UniProtKB:D2IT41"
FT                   /id="PRO_0000423518"
FT   MOD_RES         80
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P08871"
SQ   SEQUENCE   82 AA;  9532 MW;  DB5BC84ED8807A36 CRC64;
     MIGKYLSWFM LAFLFGFVLE SYRVQSQDLN PTEKEVLSNM LDFLQRHSRT TYMFPLLSES
     KRNSELINSL LGAPRVLNNA GR
 
 
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