PDH_CAMFO
ID PDH_CAMFO Reviewed; 80 AA.
AC E2AX75;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Pigment-dispersing hormone peptides {ECO:0000250|UniProtKB:D2IT41};
DE Contains:
DE RecName: Full=Pigment-dispersing factor {ECO:0000303|PubMed:25641051};
DE Short=PDF {ECO:0000303|PubMed:25641051};
DE Flags: Precursor;
GN ORFNames=EAG_01710 {ECO:0000312|EMBL:EFN61958.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 61-78, TISSUE SPECIFICITY, MASS SPECTROMETRY,
RP IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT ALA-78.
RX PubMed=25641051; DOI=10.1021/pr5011636;
RA Schmitt F., Vanselow J.T., Schlosser A., Kahnt J., Roessler W., Wegener C.;
RT "Neuropeptidomics of the carpenter ant Camponotus floridanus.";
RL J. Proteome Res. 14:1504-1514(2015).
CC -!- FUNCTION: Neuropeptide PDF is the main transmitter regulating circadian
CC locomotor rhythms. {ECO:0000250|UniProtKB:O96690}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25641051}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain (at protein level).
CC {ECO:0000269|PubMed:25641051}.
CC -!- MASS SPECTROMETRY: [Pigment-dispersing factor]: Mass=1964.04;
CC Method=Electrospray; Evidence={ECO:0000269|PubMed:25641051};
CC -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR EMBL; GL443520; EFN61958.1; -; Genomic_DNA.
DR RefSeq; XP_011265559.1; XM_011267257.1.
DR AlphaFoldDB; E2AX75; -.
DR GeneID; 105256952; -.
DR KEGG; cfo:105256952; -.
DR InParanoid; E2AX75; -.
DR OMA; AAPRFCH; -.
DR OrthoDB; 1642219at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR InterPro; IPR009396; Pigment_DH.
DR Pfam; PF06324; Pigment_DH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..80
FT /note="Pigment-dispersing hormone peptides"
FT /evidence="ECO:0000255"
FT /id="PRO_0000434240"
FT PROPEP 21..58
FT /evidence="ECO:0000305|PubMed:25641051"
FT /id="PRO_0000434241"
FT PEPTIDE 61..78
FT /note="Pigment-dispersing factor"
FT /evidence="ECO:0000269|PubMed:25641051"
FT /id="PRO_0000434242"
FT MOD_RES 78
FT /note="Alanine amide"
FT /evidence="ECO:0000269|PubMed:25641051"
SQ SEQUENCE 80 AA; 8785 MW; 3EC7B44E506883C5 CRC64;
MANYITIAII VGIVCGQALS VEDVDRNLLE LNLPYGRGLD SELQLARLML AAPRFCHPKR
NSELINSLLG LPKNMHNAGK
