ID   PDH_CARMA               Reviewed;          78 AA.
AC   Q06202;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Pigment-dispersing hormone peptides;
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide;
DE              Short=PRPP;
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone;
DE              Short=PDH;
DE     AltName: Full=Light-adapting distal retinal pigment hormone;
DE              Short=DRPH;
DE   Flags: Precursor;
OS   Carcinus maenas (Common shore crab) (Green crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Carcinidae; Carcinus.
OX   NCBI_TaxID=6759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=1282803; DOI=10.1016/0006-291x(92)90246-h;
RA   Klein J.M., de Kleijn D.P.V., Keller R., Weidemann W.M.;
RT   "Molecular cloning of crustacean pigment dispersing hormone precursor.";
RL   Biochem. Biophys. Res. Commun. 189:1509-1514(1992).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in eyestalk tissue and cerebral ganglia.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; L08635; AAA27885.1; -; mRNA.
DR   PIR; JC1406; JC1406.
DR   AlphaFoldDB; Q06202; -.
DR   SMR; Q06202; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Hormone; Neurotransmitter;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..55
FT                   /note="PDH precursor-related peptide"
FT                   /id="PRO_0000023431"
FT   PEPTIDE         58..75
FT                   /note="Pigment-dispersing hormone"
FT                   /id="PRO_0000023432"
FT   MOD_RES         75
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8557 MW;  6ED11D163D512870 CRC64;
     MRSAVIVTML VVVALAALLT QGQDLKYQER EMVAELAQQI YRVAQAPWAG AVGPHKRNSE
     LINSILGLPK VMNDAGRR