ID   PDH_EURPU               Reviewed;          83 AA.
AC   D2IT41;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Pigment-dispersing hormone peptides {ECO:0000303|PubMed:21192084};
DE   Contains:
DE     RecName: Full=PDH precursor-related peptide {ECO:0000303|PubMed:21192084};
DE              Short=PPRP {ECO:0000303|PubMed:21192084};
DE   Contains:
DE     RecName: Full=Pigment-dispersing hormone {ECO:0000303|PubMed:21192084};
DE              Short=PDH {ECO:0000303|PubMed:21192084};
DE   Flags: Precursor;
OS   Eurydice pulchra (Speckled sea louse).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Peracarida; Isopoda; Cirolanidae; Eurydice.
OX   NCBI_TaxID=155694;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ACX49752.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 63-80, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, AND MASS SPECTROMETRY.
RC   TISSUE=Head {ECO:0000269|PubMed:21192084};
RX   PubMed=21192084; DOI=10.1002/cne.22533;
RA   Wilcockson D.C., Zhang L., Hastings M.H., Kyriacou C.P., Webster S.G.;
RT   "A novel form of pigment-dispersing hormone in the central nervous system
RT   of the intertidal marine isopod, Eurydice pulchra (leach).";
RL   J. Comp. Neurol. 519:562-575(2011).
CC   -!- FUNCTION: The pigment-dispersing hormone causes the migration of the
CC       distal retinal pigment into the proximal end of the pigment
CC       chromatophore cells and thus decreases the amount of light entering the
CC       retinulas. May also function as a neurotransmitter and/or
CC       neuromodulator (By similarity). {ECO:0000250|UniProtKB:Q06202}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Strongly expressed in eyestalk tissue and cerebral
CC       ganglia (at protein level). {ECO:0000269|PubMed:21192084}.
CC   -!- DEVELOPMENTAL STAGE: Does not display circadian or circatidal patterns
CC       of expression. {ECO:0000269|PubMed:21192084}.
CC   -!- MASS SPECTROMETRY: [Pigment-dispersing hormone]: Mass=1913.83;
CC       Method=MALDI; Evidence={ECO:0000269|PubMed:21192084};
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000255}.
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DR   EMBL; GQ380440; ACX49752.1; -; mRNA.
DR   AlphaFoldDB; D2IT41; -.
DR   SMR; D2IT41; -.
DR   GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0051904; P:pigment granule transport; NAS:UniProtKB.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Neuropeptide; Neurotransmitter; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..60
FT                   /note="PDH precursor-related peptide"
FT                   /evidence="ECO:0000255, ECO:0000303|PubMed:21192084"
FT                   /id="PRO_5000555737"
FT   PEPTIDE         63..80
FT                   /note="Pigment-dispersing hormone"
FT                   /evidence="ECO:0000269|PubMed:21192084"
FT                   /id="PRO_5000555738"
FT   MOD_RES         80
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P09929"
SQ   SEQUENCE   83 AA;  9173 MW;  05A94B345BF72742 CRC64;
     MRFIILGVLF IAVASMILSN GVMAQSRDFS ISEREIVASL AKQLLRVARM GYVPEGDLPR
     KRNAELINSL LGVPRVMSDA GRR