ID   ASP_ANCCA               Reviewed;         424 AA.
AC   Q16937; A0A368GXE3;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Ancylostoma secreted protein;
DE   AltName: Full=SCP-like protein {ECO:0000312|EMBL:RCN48248.1};
DE   Flags: Precursor;
GN   Name=ASP; ORFNames=ANCCAN_05663 {ECO:0000312|EMBL:RCN48248.1};
OS   Ancylostoma caninum (Dog hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=29170;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8636085; DOI=10.1074/jbc.271.12.6672;
RA   Hawdon J.M., Jones B.F., Hoffman D.R., Hotez P.J.;
RT   "Cloning and characterization of Ancylostoma-secreted protein. A novel
RT   protein associated with the transition to parasitism by infective hookworm
RT   larvae.";
RL   J. Biol. Chem. 271:6672-6678(1996).
RN   [2] {ECO:0000312|EMBL:RCN48248.1, ECO:0000312|Proteomes:UP000252519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Baltimore;
RA   Mitreva M.;
RT   "Draft genome of the hookworm Ancylostoma caninum.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associated with the transition to parasitism by infective
CC       hookworm larvae.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; U26187; AAC47001.1; -; mRNA.
DR   EMBL; JOJR01000049; RCN48248.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q16937; -.
DR   SMR; Q16937; -.
DR   Proteomes; UP000252519; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 2.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 3.
DR   Pfam; PF00188; CAP; 2.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 2.
DR   SUPFAM; SSF55797; SSF55797; 2.
DR   PROSITE; PS01009; CRISP_1; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..424
FT                   /note="Ancylostoma secreted protein"
FT                   /id="PRO_0000006298"
FT   DOMAIN          41..177
FT                   /note="SCP 1"
FT   DOMAIN          242..387
FT                   /note="SCP 2"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        92
FT                   /note="A -> G (in Ref. 2; RCN48248)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   424 AA;  45735 MW;  4BC8295F5D3035F9 CRC64;
     MFSPVIVSVI FTIAFCDASP ARDGFGCSNS GITDKDRQAF LDFHNNARRR VAKGVEDSNS
     GKLNPAKNMY KLSWDCAMEQ QLQDAIQSCP SAFAGIQGVA QNVMSWSSSG GFPDPSVKIE
     QTLSGWWSGA KKNGVGPDNK YNGGGLFAFS NMVYSETTKL GCAYKVCGTK LAVSCIYNGV
     GYITNQPMWE TGQACKTGAD CSTYKNSGCE DGLCTKGPDV PETNQQCPSN TGMTDSVRDT
     FLSVHNEFRS SVARGLEPDA LGGNAPKAAK MLKMVYDCEV EASAIRHGNK CVYQHSHGED
     RPGLGENIYK TSVLKFDKNK AAKQASQLWW NELKEFGVGP SNVLTTALWN RPGMQIGHYT
     QMAWDTTYKL GCAVVFCNDF TFGVCQYGPG GNYMGHVIYT MGQPCSQCSP GATCSVTEGL
     CSAP