ID   PDH_PANBO               Reviewed;          18 AA.
AC   P01209;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Pigment-dispersing hormone;
DE            Short=PDH;
DE   AltName: Full=Light-adapting distal retinal pigment hormone;
DE            Short=DRPH;
OS   Pandalus borealis (Northern red shrimp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Caridea;
OC   Pandaloidea; Pandalidae; Pandalus.
OX   NCBI_TaxID=6703;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ALA-18.
RX   PubMed=952951; DOI=10.1016/0005-2795(76)90155-0;
RA   Fernlund P.;
RT   "Structure of a light-adapting hormone from the shrimp, Pandalus
RT   borealis.";
RL   Biochim. Biophys. Acta 439:17-25(1976).
CC   -!- FUNCTION: Causes the migration of the distal retinal pigment into the
CC       proximal end of the pigment chromatophore cells and thus decreases the
CC       amount of light entering the retinulas. May also function as a
CC       neurotransmitter and/or neuromodulator.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   PIR; A01473; DRDPPP.
DR   AlphaFoldDB; P01209; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neurotransmitter; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Pigment-dispersing hormone"
FT                   /id="PRO_0000044234"
FT   MOD_RES         18
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:952951"
SQ   SEQUENCE   18 AA;  1903 MW;  B2346B6D0178650E CRC64;
     NSGMINSILG IPRVMTEA