ID   PDH_ROMMI               Reviewed;          89 AA.
AC   P09929;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Pigment-dispersing hormone peptides;
DE   Contains:
DE     RecName: Full=PDF precursor-related peptide;
DE   Contains:
DE     RecName: Full=Pigment-dispersing factor;
DE              Short=PDF;
DE   Flags: Precursor;
OS   Romalea microptera (Eastern lubber grasshopper) (Romalea guttata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Orthoptera; Caelifera; Acrididea; Acridomorpha;
OC   Acridoidea; Romaleidae; Romaleinae; Romalea.
OX   NCBI_TaxID=7007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Davis D.C., Riehm J.P., Rao K.R., Keller R., Klein J.M.;
RL   Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 69-86, FUNCTION, CHARACTERISTICS, AND AMIDATION AT
RP   ALA-86.
RX   PubMed=3818616; DOI=10.1016/s0021-9258(18)61559-5;
RA   Rao K.R., Mohrherr C.J., Riehm J.P., Zahnow C.A., Norton S., Johnson L.,
RA   Tarr G.E.;
RT   "Primary structure of an analog of crustacean pigment-dispersing hormone
RT   from the lubber grasshopper Romalea microptera.";
RL   J. Biol. Chem. 262:2672-2675(1987).
CC   -!- FUNCTION: Capable of inducing pigment dispersion in the chromatophores
CC       of the fiddler crab Uca pugilator. {ECO:0000269|PubMed:3818616}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod PDH family. {ECO:0000305}.
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DR   EMBL; U42472; AAA90959.1; -; mRNA.
DR   PIR; A29558; A29558.
DR   AlphaFoldDB; P09929; -.
DR   SMR; P09929; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0009416; P:response to light stimulus; IEA:InterPro.
DR   InterPro; IPR009396; Pigment_DH.
DR   Pfam; PF06324; Pigment_DH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..66
FT                   /note="PDF precursor-related peptide"
FT                   /id="PRO_0000023435"
FT   PEPTIDE         69..86
FT                   /note="Pigment-dispersing factor"
FT                   /id="PRO_0000023436"
FT   MOD_RES         86
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:3818616"
SQ   SEQUENCE   89 AA;  9842 MW;  84A9BEE9E999526A CRC64;
     MTAMAVSGKL LTALVLSTYI LGLALTIQAT QYEEDKYQEN EVKYGRELAS WLAQLAHKNE
     PAICAHKRNS EIINSLLGLP KLLNDAGRK