PDI51_ARATH
ID PDI51_ARATH Reviewed; 146 AA.
AC Q8GYD1; Q96313; Q9LN11;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein disulfide-isomerase 5-1;
DE Short=AtPDIL5-1;
DE AltName: Full=Protein disulfide-isomerase 6-1;
DE Short=AtPDIL6-1;
DE Flags: Precursor;
GN Name=PDIL5-1; Synonyms=PDIL6-1; OrderedLocusNames=At1g07960;
GN ORFNames=T6D22.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=2615757; DOI=10.1007/bf00261164;
RA Axelos M., Bardet C., Liboz T., Le van Thai A., Curie C., Lescure B.;
RT "The gene family encoding the Arabidopsis thaliana translation elongation
RT factor EF-1 alpha: molecular cloning, characterization and expression.";
RL Mol. Gen. Genet. 219:106-112(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15684019; DOI=10.1104/pp.104.056507;
RA Houston N.L., Fan C., Xiang J.Q., Schulze J.M., Jung R., Boston R.S.;
RT "Phylogenetic analyses identify 10 classes of the protein disulfide
RT isomerase family in plants, including single-domain protein disulfide
RT isomerase-related proteins.";
RL Plant Physiol. 137:762-778(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20525253; DOI=10.1186/1471-2229-10-101;
RA d'Aloisio E., Paolacci A.R., Dhanapal A.P., Tanzarella O.A., Porceddu E.,
RA Ciaffi M.;
RT "The protein disulfide isomerase gene family in bread wheat (T. aestivum
RT L.).";
RL BMC Plant Biol. 10:101-101(2010).
CC -!- FUNCTION: Acts as a protein-folding catalyst that interacts with
CC nascent polypeptides to catalyze the formation, isomerization, and
CC reduction or oxidation of disulfide bonds. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB07885.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAF79823.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U63815; AAB07885.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC026875; AAF79823.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CP002684; AEE28218.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28219.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28220.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58216.1; -; Genomic_DNA.
DR EMBL; BT004994; AAO50527.1; -; mRNA.
DR EMBL; AK117714; BAC42365.1; -; mRNA.
DR RefSeq; NP_001318951.1; NM_001331745.1.
DR RefSeq; NP_172274.1; NM_100670.2.
DR RefSeq; NP_973787.1; NM_202058.2.
DR RefSeq; NP_973788.1; NM_202059.3.
DR AlphaFoldDB; Q8GYD1; -.
DR SMR; Q8GYD1; -.
DR BioGRID; 22552; 1.
DR STRING; 3702.AT1G07960.2; -.
DR SwissPalm; Q8GYD1; -.
DR PaxDb; Q8GYD1; -.
DR PRIDE; Q8GYD1; -.
DR ProteomicsDB; 236667; -.
DR DNASU; 837311; -.
DR EnsemblPlants; AT1G07960.1; AT1G07960.1; AT1G07960.
DR EnsemblPlants; AT1G07960.2; AT1G07960.2; AT1G07960.
DR EnsemblPlants; AT1G07960.3; AT1G07960.3; AT1G07960.
DR EnsemblPlants; AT1G07960.4; AT1G07960.4; AT1G07960.
DR GeneID; 837311; -.
DR Gramene; AT1G07960.1; AT1G07960.1; AT1G07960.
DR Gramene; AT1G07960.2; AT1G07960.2; AT1G07960.
DR Gramene; AT1G07960.3; AT1G07960.3; AT1G07960.
DR Gramene; AT1G07960.4; AT1G07960.4; AT1G07960.
DR KEGG; ath:AT1G07960; -.
DR Araport; AT1G07960; -.
DR TAIR; locus:2205145; AT1G07960.
DR eggNOG; KOG0191; Eukaryota.
DR HOGENOM; CLU_090389_4_2_1; -.
DR InParanoid; Q8GYD1; -.
DR OMA; HAYPTFK; -.
DR OrthoDB; 1481386at2759; -.
DR PhylomeDB; Q8GYD1; -.
DR PRO; PR:Q8GYD1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GYD1; baseline and differential.
DR Genevisible; Q8GYD1; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0003756; F:protein disulfide isomerase activity; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Redox-active center; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..146
FT /note="Protein disulfide-isomerase 5-1"
FT /id="PRO_0000400024"
FT DOMAIN 26..133
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT ACT_SITE 55
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 58
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT SITE 119
FT /note="Lowers pKa of C-terminal Cys of active site"
FT /evidence="ECO:0000250"
FT DISULFID 55..58
FT /note="Redox-active"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ SEQUENCE 146 AA; 16565 MW; 51B398C0853327ED CRC64;
MTLGARLVAP MIILLLFIPI ELVKAEVITL TPETFSDKIK EKDTAWFVKF CVPWCKHCKK
LGNLWEDLGK AMEGDDEIEV GEVDCGTSRA VCTKVEIHSY PTFMLFYNGE EVSKYKGKRD
VESLKAFVVE ETEKAAEKAQ LEDKEL
