ID   ASQA_EMENI              Reviewed;         565 AA.
AC   Q5AR44; C8VJP3;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Transcription factor asqA {ECO:0000303|PubMed:25251934};
DE   AltName: Full=4'-methoxyviridicatin/aspoquinolone biosynthesis cluster protein asqA {ECO:0000305};
DE   AltName: Full=Aspoquinolone biosynthesis protein A {ECO:0000303|PubMed:25251934};
GN   Name=asqA {ECO:0000303|PubMed:25251934}; ORFNames=AN9236;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   FUNCTION.
RX   PubMed=25251934; DOI=10.1002/anie.201407920;
RA   Ishikawa N., Tanaka H., Koyama F., Noguchi H., Wang C.C., Hotta K.,
RA   Watanabe K.;
RT   "Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems
RT   to form the 6,6-quinolone core of viridicatin-type fungal alkaloids.";
RL   Angew. Chem. Int. Ed. 53:12880-12884(2014).
CC   -!- FUNCTION: Transcription factor that regulates specifically the 4'-
CC       methoxyviridicatin/aspoquinolone biosynthesis cluster
CC       (PubMed:25251934). {ECO:0000269|PubMed:25251934}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; BN001306; CBF82261.1; -; Genomic_DNA.
DR   EMBL; AACD01000170; EAA61527.1; -; Genomic_DNA.
DR   RefSeq; XP_682505.1; XM_677413.1.
DR   AlphaFoldDB; Q5AR44; -.
DR   EnsemblFungi; CBF82261; CBF82261; ANIA_09236.
DR   EnsemblFungi; EAA61527; EAA61527; AN9236.2.
DR   GeneID; 2868051; -.
DR   KEGG; ani:AN9236.2; -.
DR   VEuPathDB; FungiDB:AN9236; -.
DR   eggNOG; ENOG502SIGA; Eukaryota.
DR   HOGENOM; CLU_016509_1_0_1; -.
DR   InParanoid; Q5AR44; -.
DR   OMA; FWQSYHC; -.
DR   OrthoDB; 876077at2759; -.
DR   Proteomes; UP000000560; Chromosome VI.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0000435; P:positive regulation of transcription from RNA polymerase II promoter by galactose; IBA:GO_Central.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   SMART; SM00906; Fungal_trans; 1.
PE   4: Predicted;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..565
FT                   /note="Transcription factor asqA"
FT                   /id="PRO_0000437609"
FT   REGION          204..273
FT                   /note="Fungal transcription factor domain"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  63069 MW;  A4A8CA703429E8C7 CRC64;
     MPKRVLKGAA KRAREAKHAR DAAKARRLSS FLNVRLNQEH IPHEILPNSA SDDKLLDRPV
     TGADLFAPSS GPSSNSVYPS LLQEEYFWNY FWQTYHVSLC PILDDAQFKQ HYQSLLIADG
     KGRKPSALVD IVVAACMQYH ISTLPLGSQS GLVEGKDASV AGRWHYWRGQ TLLTYELESL
     SISTLQCHVL CSIYLCGGSF HNMMDTAMAQ AVRTAYILGL HRDLPSTLPE AKREMRRRLW
     WTVYFMDTRA TMKLGRSFML SESHSMPALC IDSLRVAASS GSTFVPADED MTWLSFNLRQ
     ITLCRTFRAA YTSFHNTDFH LQEGQPIWDR PDALQAGAEI IAKHIPSLDA WCDSVPDALK
     LKRQDSNSRP FSTDGARVVL ELSAPEWLQR QRMLLENTYH HVCVNLFRSM ICFPYQPASQ
     VHISENSLPG ELATRCAAHA IALTKLTHQV LEETSLLDGW HEAFYCQWDA VMTLIGFVLA
     YPGSGTVTLE AKSAIHLAIA VSENFGFKFA VGTSASKIVQ GLCAKSETLT ANEYASAYIG
     ASTQNANIYR IYGGQICGVI DWQNS