ID   PDK1L_DANRE             Reviewed;         341 AA.
AC   Q32PP3;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Serine/threonine-protein kinase pdik1l;
DE            EC=2.7.11.1;
GN   Name=pdik1l; ORFNames=zgc:123209;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- CAUTION: Glu-37 is present instead of the conserved Lys which is
CC       expected to be an active site residue. Lys-38 may fulfill that role.
CC       {ECO:0000305}.
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DR   EMBL; BC108040; AAI08041.1; -; mRNA.
DR   RefSeq; NP_001032789.2; NM_001037700.2.
DR   AlphaFoldDB; Q32PP3; -.
DR   SMR; Q32PP3; -.
DR   STRING; 7955.ENSDARP00000073471; -.
DR   PaxDb; Q32PP3; -.
DR   GeneID; 569665; -.
DR   KEGG; dre:569665; -.
DR   CTD; 149420; -.
DR   ZFIN; ZDB-GENE-051113-236; pdik1l.
DR   eggNOG; KOG0595; Eukaryota.
DR   InParanoid; Q32PP3; -.
DR   PhylomeDB; Q32PP3; -.
DR   PRO; PR:Q32PP3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..341
FT                   /note="Serine/threonine-protein kinase pdik1l"
FT                   /id="PRO_0000086497"
FT   DOMAIN          8..332
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        164
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         14..22
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   341 AA;  38205 MW;  40318DE00BEF0778 CRC64;
     MVSSQAKYEL IQEVGRGSYG VVYEAVVRQT GARVAVEKIR CHSPENVELA LREFWALSSI
     QSQHPNVIHL EECVLQRDAL AQRMSHGSSS SLYLELVETS LKGEITFDPC CAYYMWFVMD
     FCDGGDMNAY LLSRKPSRKT NTSFMLQLGS ALAFLHRNQI IHRDLKPDNI LISQGRTPAG
     SPEPTLKVAD FGLSKVCSGS GLNPEEPASV NKCFLSTACG TDFYMAPEVW EGHYTAKADI
     FALGVIIWAM VERITFVDVE TQKELLGSYV QQGEDIVPLG EALLENPKME LNIPARKKSM
     NASMKQLIRE MLSANPQERP DAFELELRLV RIACRELDWD T