ID   PDLI3_BOVIN             Reviewed;         316 AA.
AC   Q3SYZ8;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=PDZ and LIM domain protein 3;
GN   Name=PDLIM3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the organization of actin filament arrays
CC       within muscle cells. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACTN2 (By similarity). Forms a heterodimer with
CC       PDLIM4 (via LIM domain) (By similarity). {ECO:0000250|UniProtKB:O70209,
CC       ECO:0000250|UniProtKB:Q66HS7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}. Note=Localizes to myofiber Z-lines. {ECO:0000250}.
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DR   EMBL; BC103313; AAI03314.1; -; mRNA.
DR   RefSeq; NP_001029818.1; NM_001034646.1.
DR   AlphaFoldDB; Q3SYZ8; -.
DR   SMR; Q3SYZ8; -.
DR   STRING; 9913.ENSBTAP00000022835; -.
DR   PaxDb; Q3SYZ8; -.
DR   PeptideAtlas; Q3SYZ8; -.
DR   Ensembl; ENSBTAT00000022835; ENSBTAP00000022835; ENSBTAG00000017183.
DR   GeneID; 538516; -.
DR   KEGG; bta:538516; -.
DR   CTD; 27295; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017183; -.
DR   VGNC; VGNC:32709; PDLIM3.
DR   eggNOG; KOG1703; Eukaryota.
DR   GeneTree; ENSGT00940000156741; -.
DR   HOGENOM; CLU_038114_1_1_1; -.
DR   InParanoid; Q3SYZ8; -.
DR   OMA; IHAQFNT; -.
DR   OrthoDB; 840552at2759; -.
DR   TreeFam; TF106408; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000017183; Expressed in supraspinatus muscle and 105 other tissues.
DR   ExpressionAtlas; Q3SYZ8; baseline.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0031941; C:filamentous actin; IBA:GO_Central.
DR   GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051371; F:muscle alpha-actinin binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0061061; P:muscle structure development; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR031847; DUF4749.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR006643; Zasp-like_motif.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF15936; DUF4749; 1.
DR   Pfam; PF00412; LIM; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00132; LIM; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00735; ZM; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; LIM domain; Metal-binding; Methylation; Phosphoprotein;
KW   Reference proteome; Zinc.
FT   CHAIN           1..316
FT                   /note="PDZ and LIM domain protein 3"
FT                   /id="PRO_0000075866"
FT   DOMAIN          1..84
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          244..303
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   MOD_RES         18
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66HS7"
FT   MOD_RES         164
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:O70209"
SQ   SEQUENCE   316 AA;  34353 MW;  BDA760FB4109A408 CRC64;
     MPQNVVLPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM
     THADAQDRIK AAGHQLCLKI DRAEARLWSP QVTEDGKAHP FKINLESEPQ EFKPIGAAHN
     RRAQPFVAAA NIDDKRQVVS ASYNSPIGLY STSNIQDALH GQLRGLIPSS PQNEPTASVP
     PESDVYRMLH DNRNEPTQPR QSGSFRVLQE LVNDGADDRP AGTRSVRAPV TKVHGGAGGT
     QKMPFCDKCG SGIVGAVVKA RDKYRHPECF VCADCNLNLK QKGYFFVEGE LYCETHARAR
     MRPPEGYDTV TLYPKA