PDLI3_PIG
ID PDLI3_PIG Reviewed; 365 AA.
AC Q6QGC0;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=PDZ and LIM domain protein 3;
DE AltName: Full=Actinin-associated LIM protein;
DE AltName: Full=Alpha-actinin-2-associated LIM protein;
GN Name=PDLIM3;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Tian X., Li J., Wang C., Chen Y.;
RT "The cloning and expression of alpha-actinin-2-associated LIM protein gene
RT in pig.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in the organization of actin filament arrays
CC within muscle cells. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ACTN2 (By similarity). Forms a heterodimer with
CC PDLIM4 (via LIM domain) (By similarity). {ECO:0000250|UniProtKB:O70209,
CC ECO:0000250|UniProtKB:Q66HS7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000250}. Note=Localizes to myofiber Z-lines. {ECO:0000250}.
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DR EMBL; AY543095; AAS55866.1; -; mRNA.
DR RefSeq; NP_001001637.1; NM_001001637.1.
DR AlphaFoldDB; Q6QGC0; -.
DR SMR; Q6QGC0; -.
DR STRING; 9823.ENSSSCP00000016738; -.
DR PaxDb; Q6QGC0; -.
DR PeptideAtlas; Q6QGC0; -.
DR PRIDE; Q6QGC0; -.
DR Ensembl; ENSSSCT00000017199; ENSSSCP00000016738; ENSSSCG00000015796.
DR Ensembl; ENSSSCT00005056527; ENSSSCP00005034788; ENSSSCG00005034876.
DR Ensembl; ENSSSCT00005056559; ENSSSCP00005034807; ENSSSCG00005034876.
DR Ensembl; ENSSSCT00015040998; ENSSSCP00015016205; ENSSSCG00015030376.
DR Ensembl; ENSSSCT00025049163; ENSSSCP00025021020; ENSSSCG00025036042.
DR Ensembl; ENSSSCT00030103959; ENSSSCP00030048109; ENSSSCG00030074128.
DR Ensembl; ENSSSCT00035018380; ENSSSCP00035006422; ENSSSCG00035014492.
DR Ensembl; ENSSSCT00040046658; ENSSSCP00040019555; ENSSSCG00040034605.
DR Ensembl; ENSSSCT00050027919; ENSSSCP00050011546; ENSSSCG00050020686.
DR Ensembl; ENSSSCT00055030210; ENSSSCP00055024065; ENSSSCG00055015298.
DR Ensembl; ENSSSCT00060084157; ENSSSCP00060036458; ENSSSCG00060060611.
DR Ensembl; ENSSSCT00060084186; ENSSSCP00060036471; ENSSSCG00060060611.
DR Ensembl; ENSSSCT00065093889; ENSSSCP00065041086; ENSSSCG00065068360.
DR Ensembl; ENSSSCT00070054507; ENSSSCP00070046233; ENSSSCG00070027183.
DR GeneID; 414421; -.
DR KEGG; ssc:414421; -.
DR CTD; 27295; -.
DR VGNC; VGNC:95945; PDLIM3.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00940000156741; -.
DR InParanoid; Q6QGC0; -.
DR OrthoDB; 840552at2759; -.
DR TreeFam; TF106408; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Proteomes; UP000314985; Chromosome 15.
DR Bgee; ENSSSCG00000015796; Expressed in muscle tissue and 44 other tissues.
DR ExpressionAtlas; Q6QGC0; baseline and differential.
DR Genevisible; Q6QGC0; SS.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IBA:GO_Central.
DR GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051371; F:muscle alpha-actinin binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR GO; GO:0061061; P:muscle structure development; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR031847; DUF4749.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR006643; Zasp-like_motif.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF15936; DUF4749; 1.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00735; ZM; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; LIM domain; Metal-binding; Phosphoprotein; Reference proteome;
KW Zinc.
FT CHAIN 1..365
FT /note="PDZ and LIM domain protein 3"
FT /id="PRO_0000075869"
FT DOMAIN 1..84
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 293..352
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 126..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q66HS7"
SQ SEQUENCE 365 AA; 39546 MW; B66EE3A4CF35FCAA CRC64;
MPQNVILPGP APWGFRLSGG IDFNQPLIIT RITPGSKAAA ANLCPGDVIL AIDGYGTESM
THADAQDRIK AAAHQLCLKI DRAETRLWSP QVTEDGKAHP FKINLESEPQ DVNYFEHKHN
IRPKPFIIPG RSSGCSTPSG IDGGSGRSTP SSVSTLSTIC PGDLKVAAKM APNIPLEMEL
PGVKIVHAQF NTPMQLYSDD NIMETLQGQV STALGETPSM SEPTTASVPP QSDVYRMLHD
NRNEPTQPRQ SGSFRVLQEL VNDGPDDRPA GTRSVRAPVT KIHGGAGGTQ KMPLCDKCGS
GIVGAVVKAR DKYRHPECFV CADCNLNLKQ KGYFFVEGEL YCETHARARM RPPEGYDTVT
LYPKA
