ID   PDLI7_DANRE             Reviewed;         419 AA.
AC   Q6P7E4;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=PDZ and LIM domain protein 7;
GN   Name=pdlim7;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a scaffold on which the coordinated assembly
CC       of proteins can occur. May play a role as an adapter that, via its PDZ
CC       domain, localizes LIM-binding proteins to actin filaments of both
CC       skeletal muscle and nonmuscle tissues (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- DOMAIN: The LIM zinc-binding 3 (LIM 3) domain provides the structural
CC       basis for recognition of tyrosine-containing tight turn structures.
CC       {ECO:0000250}.
CC   -!- DOMAIN: Anchored to cell periphery via its N-terminal PDZ domain.
CC       {ECO:0000250}.
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DR   EMBL; BC061704; AAH61704.1; -; mRNA.
DR   RefSeq; NP_957134.1; NM_200840.1.
DR   AlphaFoldDB; Q6P7E4; -.
DR   SMR; Q6P7E4; -.
DR   GeneID; 393813; -.
DR   KEGG; dre:393813; -.
DR   CTD; 9260; -.
DR   ZFIN; ZDB-GENE-040426-2092; pdlim7.
DR   InParanoid; Q6P7E4; -.
DR   OrthoDB; 1013114at2759; -.
DR   PhylomeDB; Q6P7E4; -.
DR   Reactome; R-DRE-8853659; RET signaling.
DR   PRO; PR:Q6P7E4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0015629; C:actin cytoskeleton; IPI:ZFIN.
DR   GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR   GO; GO:0031941; C:filamentous actin; IDA:ZFIN.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ZFIN.
DR   GO; GO:0001725; C:stress fiber; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051371; F:muscle alpha-actinin binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0003294; P:atrial ventricular junction remodeling; IMP:ZFIN.
DR   GO; GO:0003190; P:atrioventricular valve formation; IMP:ZFIN.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IGI:ZFIN.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR   GO; GO:0061061; P:muscle structure development; IBA:GO_Central.
DR   GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
DR   GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 3.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00132; LIM; 3.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Reference proteome;
KW   Repeat; Zinc.
FT   CHAIN           1..419
FT                   /note="PDZ and LIM domain protein 7"
FT                   /id="PRO_0000075885"
FT   DOMAIN          1..85
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          242..300
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          301..360
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          361..419
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          174..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  45592 MW;  E1867735ABACB3CE CRC64;
     MNIYCVTLNG PAPWGFRLQG GKDFNTPLTV SRLTPGGKAA QAGVGVGDWV VSIFDANAEE
     MTHVEAQNKI RAATDSLKLT LSRAFHPAGG EQKDSLTSSS SQPKYSFAPS TAINKMARPF
     SASPGSGSAG PVIKPVSYAL KPALSSPHNG HGVAPCPVTV KSKPADKHDA VQAPAKAPVS
     SGPACRPPWV TDPGFADRYH PDKSSTVVTQ HTQPLQPTPM QNRSSILQAA QQSPAHSSTA
     TPLCAACSKI IRGRYVVALG RSWHPEEFMC CQCKRLLDEG GFFEEKGSIY CSKCYDNRYS
     PNCAKCKKII TGEIMHALKM TYHVQCFLCA ACKLPIRNQA FYMEEGEPYC ERDYEKMFGT
     KCHGCDFKID AGDRFLEALG YSWHDTCFVC AICQINLEGK TFYSKKDKPL CKSHAFSPL