ID   PDM2_DROVI              Reviewed;         471 AA.
AC   Q24705;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=POU domain protein 2;
DE   AltName: Full=Miti-mere;
DE   AltName: Full=Pdm-2;
DE   AltName: Full=Protein didymous;
DE   AltName: Full=dOct2;
DE   AltName: Full=dPOU-28;
DE   Flags: Fragment;
GN   Name=pdm2; Synonyms=dim, OCT2, pdm-2, POU-28;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=7748782; DOI=10.1016/0925-4773(94)00307-9;
RA   Poole S.J.;
RT   "Conservation of complex expression domains of the pdm-2 POU domain gene
RT   between Drosophila virilis and Drosophila melanogaster.";
RL   Mech. Dev. 49:107-116(1995).
CC   -!- FUNCTION: DNA-binding regulatory protein implicated in early
CC       development. Involved in neuronal cell fate decision. May act as an
CC       octamer-dependent activator of transcription (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed primarily during the first half of
CC       embryogenesis. Initial expression in cellular blastoderm stage, then in
CC       ectodermal stripes during germband extension. Broad expression in the
CC       neuroectoderm followed by limitation to discrete subsets of CNS cells,
CC       and expression in specific PNS neurons and support cells.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U14723; AAA21584.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24705; -.
DR   SMR; Q24705; -.
DR   STRING; 7244.FBpp0230691; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0007417; P:central nervous system development; IEA:EnsemblMetazoa.
DR   GO; GO:0007398; P:ectoderm development; IEA:EnsemblMetazoa.
DR   GO; GO:0014019; P:neuroblast development; IEA:EnsemblMetazoa.
DR   GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:EnsemblMetazoa.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..471
FT                   /note="POU domain protein 2"
FT                   /id="PRO_0000100779"
FT   DOMAIN          257..331
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        362..421
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   471 AA;  51226 MW;  B0D27F895EC2428C CRC64;
     CGKSYEEEEE EEDDELEADV AQNLSSKRSA RQLDADMENE VLNLARSVSP AAKRLALEHT
     AEPALAAQSA AAATPPVGLS LPPTAPLGFG PEDMQQALQL QLHSYIEMVR QLAPDAFPNP
     NLATQFLLQN SLQALAQFQA LQQLKQQRDQ QLPTASEQLP TRHYSTPLSK SPLRSPSLSP
     VARSMEPQQA QRTPPNSLAA AGLGLSSAVL TPNTPSMQQQ QQQTMTSTTN ASSTPKPLAS
     GATVAAVMAT KLEQSPEETT DLEELEQFAK TFKQRRIKLG FTQGDVGLAM GKLYGNDFSQ
     TTISRFEALN LSFKNMCKLK PLLQKWLEDA DSSVAKSAGG VFNINTMTTN LSSTPESILG
     RRRKKRTSIE TTIRGALEQA FVLNCKPTSE EINQLSERLH MDKEVVRVWF CNRRQKEKRI
     NPSLDLDSPT GTPLSSHAFG YPPQALNMSN GGHVLLEAGG SHCGSSISSG E