PDP2_SCHPO
ID PDP2_SCHPO Reviewed; 568 AA.
AC O94312;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=PWWP domain-containing protein2;
GN Name=pdp2; ORFNames=SPBC215.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP STRUCTURE BY NMR OF 118-225.
RX PubMed=12842472; DOI=10.1016/s0022-2836(03)00470-4;
RA Slater L.M., Allen M.D., Bycroft M.;
RT "Structural variation in PWWP domains.";
RL J. Mol. Biol. 330:571-576(2003).
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DR EMBL; CU329671; CAA22121.1; -; Genomic_DNA.
DR PIR; T39897; T39897.
DR RefSeq; NP_596684.1; NM_001022607.2.
DR PDB; 1H3Z; NMR; -; A=118-225.
DR PDBsum; 1H3Z; -.
DR AlphaFoldDB; O94312; -.
DR BMRB; O94312; -.
DR SMR; O94312; -.
DR BioGRID; 277178; 21.
DR STRING; 4896.SPBC215.07c.1; -.
DR iPTMnet; O94312; -.
DR MaxQB; O94312; -.
DR PaxDb; O94312; -.
DR PRIDE; O94312; -.
DR EnsemblFungi; SPBC215.07c.1; SPBC215.07c.1:pep; SPBC215.07c.
DR GeneID; 2540653; -.
DR KEGG; spo:SPBC215.07c; -.
DR PomBase; SPBC215.07c; pdp2.
DR VEuPathDB; FungiDB:SPBC215.07c; -.
DR eggNOG; ENOG502S5RN; Eukaryota.
DR HOGENOM; CLU_032844_0_0_1; -.
DR InParanoid; O94312; -.
DR OMA; IVCDEEM; -.
DR PhylomeDB; O94312; -.
DR EvolutionaryTrace; O94312; -.
DR PRO; PR:O94312; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; ISM:PomBase.
DR GO; GO:0033100; C:NuA3 histone acetyltransferase complex; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; ISS:PomBase.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; ISM:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:PomBase.
DR CDD; cd05840; SPBC215_ISWI_like; 1.
DR IDEAL; IID50183; -.
DR InterPro; IPR035503; IOC4-like_PWWP.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..568
FT /note="PWWP domain-containing protein2"
FT /id="PRO_0000116768"
FT DOMAIN 125..189
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..245
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 128..133
FT /evidence="ECO:0007829|PDB:1H3Z"
FT STRAND 136..143
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 146..148
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 151..155
FT /evidence="ECO:0007829|PDB:1H3Z"
FT STRAND 160..162
FT /evidence="ECO:0007829|PDB:1H3Z"
FT STRAND 165..169
FT /evidence="ECO:0007829|PDB:1H3Z"
FT TURN 170..173
FT /evidence="ECO:0007829|PDB:1H3Z"
FT STRAND 176..178
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 180..182
FT /evidence="ECO:0007829|PDB:1H3Z"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 188..196
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 203..214
FT /evidence="ECO:0007829|PDB:1H3Z"
FT HELIX 218..220
FT /evidence="ECO:0007829|PDB:1H3Z"
SQ SEQUENCE 568 AA; 62825 MW; D54F73C9F6E51991 CRC64;
MTEIKDSSVK DENPGKQEES SIAVESREMS TATNNSKNIE TTSSNGAEDI KIQRDVGDDK
DLDDKEANDK SSKGLEEESD SKDRKTIETD QPSNNIGDIK SQKSEKSNGN ARKETKQSER
VNYKPGMRVL TKMSGFPWWP SMVVTESKMT SVARKSKPKR AGTFYPVIFF PNKEYLWTGS
DSLTPLTSEA ISQFLEKPKP KTASLIKAYK MAQSTPDLDS LSVPSSESEV SEEESDQEMS
EPSPIEEDYN DTKARRITRK GTKKKTVTFD PSLESVPQKR LNASSNVSSN PAKKTRVSPR
RSTAASKKKS PSSKRASSDE IEKDKEEEEG SVANEEDVAK RTFHSREQSL LFLRHKLQSS
LLSPKQDLSQ VDYKLVHNYL DKLANFQGID VPLIQKTKIA VVVRKIFSLA GLPKENEDEV
KSICGDILEN RWKSLLQEIS SQKQLSTDAS QTQDASIANE NETEIASLDE GSESKPTPSP
PAEQLTDQKQ NEDNEDKVKA DSNGPTQNEN ETADASKDMI SEEKSSKDAD NSLEVAGKDF
AEDGTEQTPN LAEPEDGVAA VDLSTGQK
