PDP4_ARATH
ID PDP4_ARATH Reviewed; 965 AA.
AC Q9MA56;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=PWWP domain-containing protein 4 {ECO:0000303|PubMed:29314758};
GN Name=PDP4 {ECO:0000303|PubMed:29314758};
GN OrderedLocusNames=At3g05430 {ECO:0000312|Araport:AT3G05430};
GN ORFNames=F22F7.12 {ECO:0000312|EMBL:AAF64539.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DISRUPTION PHENOTYPE, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=29314758; DOI=10.1111/jipb.12630;
RA Zhou J.X., Liu Z.W., Li Y.Q., Li L., Wang B., Chen S., He X.J.;
RT "Arabidopsis PWWP domain proteins mediate H3K27 trimethylation on FLC and
RT regulate flowering time.";
RL J. Integr. Plant Biol. 60:362-368(2018).
CC -!- FUNCTION: May influence gene expression by regulating the function of
CC the PRC2 complex and modulating H3K27me3 level.
CC {ECO:0000250|UniProtKB:Q9FNE4}.
CC -!- SUBUNIT: Component of the PRC2 (polycomb repressive complex 2) complex
CC which regulates histone methylation on histone H3K27.
CC {ECO:0000250|UniProtKB:Q9FNE4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- DISRUPTION PHENOTYPE: No visible flowering phenotype.
CC {ECO:0000269|PubMed:29314758}.
CC -!- SIMILARITY: Belongs to the PDP family. {ECO:0000305}.
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DR EMBL; AC009606; AAF64539.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74240.1; -; Genomic_DNA.
DR EMBL; AB493602; BAH30440.1; -; mRNA.
DR RefSeq; NP_187194.1; NM_111416.3.
DR AlphaFoldDB; Q9MA56; -.
DR STRING; 3702.AT3G05430.1; -.
DR PaxDb; Q9MA56; -.
DR PRIDE; Q9MA56; -.
DR ProteomicsDB; 185361; -.
DR EnsemblPlants; AT3G05430.1; AT3G05430.1; AT3G05430.
DR GeneID; 819708; -.
DR Gramene; AT3G05430.1; AT3G05430.1; AT3G05430.
DR Araport; AT3G05430; -.
DR TAIR; locus:2079767; AT3G05430.
DR eggNOG; ENOG502QQX0; Eukaryota.
DR HOGENOM; CLU_006566_0_0_1; -.
DR InParanoid; Q9MA56; -.
DR OrthoDB; 982164at2759; -.
DR PhylomeDB; Q9MA56; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9MA56; baseline and differential.
DR GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR GO; GO:0098532; P:histone H3-K27 trimethylation; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR000313; PWWP_dom.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..965
FT /note="PWWP domain-containing protein 4"
FT /id="PRO_0000453272"
FT DOMAIN 135..196
FT /note="PWWP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00162"
FT REGION 437..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 546..553
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 437..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 107901 MW; D1712C282CBD7B71 CRC64;
MNSAEVNVNP RVFGDSFVTF SGNGSGKFEM IDQAEAFLME LDSVAADTGS DGNGNVDLGS
RVSNSETEPR FCEMKREIRD SDHRFYELCN ESGEKKMEKR RVPDYKSFLS EFDDYVAREK
MGSRNSKALS YGFEVGDMVW GKVKSHPWWP GQIFNEAFAS PSVRRVKKMG YVLVAFFGDN
SYGWFDPAEL IPFEPHVKEK SQQTSSDHFA KAVEEAMNEV GRRSALGLTC KCRNQYNFRP
INAQGYFAVD VPDYEVQAIY SSKQIQKARD SFSSVQTLAF VKRCALAPQE CDTDSLKSFQ
KKVAVCAFRR AVFEEFDETY EQAFRARSVY CLMKTHEPLN RAPLRVPLSG SLVSAETLGN
PKSYTKAMNV KDSTKQDKYL PKRREEAGDM TVQFGQVQES SQFQGINGSS AWDRLLQRRT
PCLQTPRKHE QTGLVSMNFT SSSGNIPGKK SSVSKLSRDD DKGLAQESDV RMGEKATLFP
DQEKFEPMKS LKQDETGTNS RSNKSSLKLF SGGKFSAGVG IKKGNVVKRS SGEMKSENCP
PEPKKKKKEY VSELNRDTPD KRKALSSGEA WAKKSSQVDS AKRRSNMLIV KLDGLQLLSN
LLALSLDPLF GSSDRSSFRV IRQFFFHFRS HVYQKSLATS PSATKLSKSA KTLCRANEQS
KAGRNRISSD SQQDVPSTKK LKKTIQFKPL ASDKKTNQDA TKRSSLAPLN PVRDQCRVPI
NAKPAIVQQE KKTGPSAMVV EPTMLVMMFP PGESLPSIDL LKARFGRFGQ LDQSAIRVSW
KSSICRVGFL YKLDAQTALR YVSGSKSLFG NVNVTYFLRD MKASSASGDH ELKKAKRPKT
DKPITKPLNQ LLEQAPPVHQ PNIQLKSCLK KPGNNRNGNH RTVRVKFMLG EKETESPFSV
SILPLSSQDS EPKPVNNQVD HVEPPLDPSQ LKVDISLQMM ELLTRCNDAV ANVTGLLGYV
PYHSL
